DSigDB: drug signatures database for gene set analysis

We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an...

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Bibliographic Details
Published in:Bioinformatics 2015-09, Vol.31 (18), p.3069-3071
Main Authors: Yoo, Minjae, Shin, Jimin, Kim, Jihye, Ryall, Karen A, Lee, Kyubum, Lee, Sunwon, Jeon, Minji, Kang, Jaewoo, Tan, Aik Choon
Format: Article
Language:English
Subjects:
Applications Notes
Bioinformatics
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - genetics
Computational Biology - methods
Computer programs
Databases, Pharmaceutical
Drug Repositioning
Drugs
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Genes
Humans
Lung Neoplasms - drug therapy
Lung Neoplasms - genetics
Mutation - genetics
Protein Kinase Inhibitors - pharmacology
Receptor, Epidermal Growth Factor - antagonists & inhibitors
Receptor, Epidermal Growth Factor - genetics
Signatures
Software
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Summary:We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research. DSigDB is freely available for non-commercial use at http://tanlab.ucdenver.edu/DSigDB. Supplementary data are available at Bioinformatics online. aikchoon.tan@ucdenver.edu.
ISSN:1367-4803
1367-4811
1460-2059
DOI:10.1093/bioinformatics/btv313