Therapeutic Transdifferentiation: A Novel Approach for Ischemic Syndromes

The technological development of induced pluripotent stem cells (iPSCs) has overcome many of the limitations of adult and embryonic stem cells. We have found that activation of innate immunity signaling is necessary for this process, as it facilitates epigenetic plasticity in cells by a process call...

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Bibliographic Details
Published in:Methodist DeBakey cardiovascular journal 2015-07, Vol.11 (3), p.176-180
Main Authors: Connell, Jennifer P, Kodali, Santhisri, Cooke, John P
Format: Article
Language:English
Subjects:
Animals
Biomarkers - metabolism
Cell Transdifferentiation
Humans
Immunity, Innate
Induced Pluripotent Stem Cells - immunology
Induced Pluripotent Stem Cells - metabolism
Induced Pluripotent Stem Cells - transplantation
Myocardial Ischemia - immunology
Myocardial Ischemia - metabolism
Myocardial Ischemia - pathology
Myocardial Ischemia - physiopathology
Myocardial Ischemia - surgery
Myocardium - immunology
Myocardium - metabolism
Myocardium - pathology
Myocytes, Cardiac - immunology
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Myocytes, Cardiac - transplantation
New Concepts and Therapies for Atherosclerosis
Phenotype
Stem Cell Transplantation - methods
Syndrome
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Summary:The technological development of induced pluripotent stem cells (iPSCs) has overcome many of the limitations of adult and embryonic stem cells. We have found that activation of innate immunity signaling is necessary for this process, as it facilitates epigenetic plasticity in cells by a process called transflammation. More recently, we have discovered that transflammation also facilitates the transdifferentiation of cells directly from one somatic cell type to another. This insight may lead to a promising therapeutic pathway that avoids reverting cells all the way back to pluripotency before achieving a cell type of interest. While there is much therapeutic promise to transflammation and transdifferentiation, there is also evidence that transdifferentiation plays a role in some pathological conditions, including atherosclerosis. Ultimately, better understanding of transflammation will facilitate the development of regenerative therapies.
ISSN:1947-6094
1947-6108
DOI:10.14797/mdcj-11-3-176