Evaluation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains

Diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and DKI-derived white matter tract integrity metrics (WMTI) were experimentally evaluated ex vivo through comparisons to histological measurements and established magnetic resonance imaging (MRI) measures of myelin in two knockout mou...

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Bibliographic Details
Published in:	NeuroImage (Orlando, Fla.) Fla.), 2016-01, Vol.124 (Pt A), p.612-626
Main Authors:	Kelm, Nathaniel D., West, Kathryn L., Carson, Robert P., Gochberg, Daniel F., Ess, Kevin C., Does, Mark D.
Format:	Article
Language:	eng
Subjects:	Animals Axons - ultrastructure Brain - ultrastructure Carrier Proteins - genetics Diffusion Diffusion Tensor Imaging - methods Disease Models, Animal Kurtosis Magnetic Resonance Imaging - methods Mice Mice, Knockout MRI Myelin Myelin Sheath - ultrastructure Quantitative histology Rapamycin-Insensitive Companion of mTOR Protein Tuberous Sclerosis - genetics Tuberous Sclerosis - pathology Tumor Suppressor Proteins - genetics White matter White Matter - ultrastructure
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Summary:	Diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and DKI-derived white matter tract integrity metrics (WMTI) were experimentally evaluated ex vivo through comparisons to histological measurements and established magnetic resonance imaging (MRI) measures of myelin in two knockout mouse models with varying degrees of hypomyelination. DKI metrics of mean and radial kurtosis were found to be better indicators of myelin content than conventional DTI metrics. The biophysical WMTI model based on the DKI framework reported on axon water fraction with good accuracy in cases with near normal axon density, but did not provide additional specificity to myelination. Overall, DKI provided additional information regarding white matter microstructure compared with DTI, making it an attractive method for future assessments of white matter development and pathology. [Display omitted]
ISSN:	1053-8119 1095-9572