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Prognostic impact of discrepant Ki67 and mitotic index on hormone receptor-positive, HER2-negative breast carcinoma

Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. We included a cohort of breast cancer patients initiall...

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Bibliographic Details
Published in:British journal of cancer 2015-09, Vol.113 (7), p.996-1002
Main Authors: Rossi, L, Laas, E, Mallon, P, Vincent-Salomon, A, Guinebretiere, J-M, Lerebours, F, Rouzier, R, Pierga, J-Y, Reyal, F
Format: Article
Language:English
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Summary:Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. We included a cohort of breast cancer patients initially treated by surgery between 2001 and 2005 in the Institut Curie. Breast cancer-specific survival (BCSS) and disease-free survival (DFS) were analysed according to three proliferation groups: high MI/high Ki67 (MI=3, Ki67>20%), low MI/low Ki67 (MI
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2015.239