Dendritic spine dynamics leading to spine elimination after repeated inductions of LTD

Memory is fixed solidly by repetition. However, the cellular mechanism underlying this repetition-dependent memory consolidation/reconsolidation remains unclear. In our previous study using stable slice cultures of the rodent hippocampus, we found long-lasting synaptic enhancement/suppression couple...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2015-01, Vol.5 (1), p.7707-7707, Article 7707
Main Authors: Hasegawa, Sho, Sakuragi, Shigeo, Tominaga-Yoshino, Keiko, Ogura, Akihiko
Format: Article
Language:English
Subjects:
Animals
Dendritic spines
Dendritic Spines - drug effects
Dendritic Spines - physiology
Fluorescent Dyes - chemistry
Hippocampus - cytology
Hippocampus - drug effects
Hippocampus - physiology
In Vitro Techniques
Long-term potentiation
Long-Term Potentiation - drug effects
Methoxyhydroxyphenylglycol - analogs & derivatives
Methoxyhydroxyphenylglycol - pharmacology
Mice
Mice, Transgenic
Microscopy, Confocal
Repetition
Rodents
Stochasticity
Synapses - physiology
Synaptogenesis
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Memory is fixed solidly by repetition. However, the cellular mechanism underlying this repetition-dependent memory consolidation/reconsolidation remains unclear. In our previous study using stable slice cultures of the rodent hippocampus, we found long-lasting synaptic enhancement/suppression coupled with synapse formation/elimination after repeated inductions of chemical LTP/LTD, respectively. We proposed these phenomena as useful model systems for analyzing repetition-dependent memory consolidation. Recently, we analyzed the dynamics of dendritic spines during development of the enhancement, and found that the spines increased in number following characteristic stochastic processes. The current study investigates spine dynamics during the development of the suppression. We found that the rate of spine retraction increased immediately leaving that of spine generation unaltered. Spine elimination occurred independent of the pre-existing spine density on the dendritic segment. In terms of elimination, mushroom-type spines were not necessarily more stable than stubby-type and thin-type spines.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep07707