Allelic variation contributes to bacterial host specificity

Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynon...

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Bibliographic Details
Published in:Nature communications 2015-10, Vol.6 (1), p.8754-8754, Article 8754
Main Authors: Yue, Min, Han, Xiangan, De Masi, Leon, Zhu, Chunhong, Ma, Xun, Zhang, Junjie, Wu, Renwei, Schmieder, Robert, Kaushik, Radhey S, Fraser, George P, Zhao, Shaohua, McDermott, Patrick F, Weill, François-Xavier, Mainil, Jacques G, Arze, Cesar, Fricke, W Florian, Edwards, Robert A, Brisson, Dustin, Zhang, Nancy R, Rankin, Shelley C, Schifferli, Dieter M
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Adaptation
Adhesins, Bacterial
Adhesins, Bacterial - chemistry
Adhesins, Bacterial - genetics
Adhesins, Bacterial - metabolism
Alleles
Amino Acid Sequence
Animals
Bacterial Adhesion
Bacterial Proteins
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Computer science
Fimbriae, Bacterial
Fimbriae, Bacterial - chemistry
Fimbriae, Bacterial - genetics
Fimbriae, Bacterial - metabolism
Food Microbiology
Genes
Genetic Variation
Genomes
Host Specificity
Humans
Infections
Infectious diseases
Laboratories
Life Sciences
Molecular Sequence Data
Médecine vétérinaire & santé animale
Pathogens
Phylogeny
Polymorphism, Single Nucleotide
Proteins
Salmonella
Salmonella Infections
Salmonella Infections - microbiology
Salmonella Infections, Animal
Salmonella Infections, Animal - microbiology
Salmonella typhimurium
Salmonella typhimurium - classification
Salmonella typhimurium - genetics
Salmonella typhimurium - isolation & purification
Salmonella typhimurium - physiology
Santé publique et épidémiologie
Sciences du vivant
Veterinary medicine
Veterinary medicine & animal health
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Summary:Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our genome-wide analysis of core genes within Salmonella enterica serovar Typhimurium genomes reveals a high degree of allelic variation in surface-exposed molecules, including adhesins that promote host colonization. Subsequent multinomial logistic regression, MultiPhen and Random Forest analyses of known/suspected adhesins from 580 independent Typhimurium isolates identifies distinct host-specific nsSNP signatures. Moreover, population and functional analyses of host-associated nsSNPs for FimH, the type 1 fimbrial adhesin, highlights the role of key allelic residues in host-specific adherence in vitro. Together, our data provide the first concrete evidence that functional differences between allelic variants of bacterial proteins likely contribute to pathoadaption to diverse hosts.
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms9754