Removal of pamidronate from bone in rats using systemic and local chelation

Highlights • This study proved the feasibility of removing bisphosphonates from bone in-vivo. • Systemic agent reduced the bisphosphonate signal from the skeleton. • This effect was due to a direct action on bone. • Local application produced a similar effect on extraction sites in the mandible. • R...

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Bibliographic Details
Published in:Archives of oral biology 2015-12, Vol.60 (12), p.1699-1707
Main Authors: Howie, R. Nicole, Bhattacharyya, Maryka, Salama, Mohamed E, Refaey, Mona El, Isales, Carlos, Borke, James, Daoudi, Asma, Medani, Fardous, Elsalanty, Mohammed E
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Bisphosphonates
Bone
Bone and Bones - metabolism
Bone Density
Cadmium - pharmacology
Calcium - metabolism
Chelating agents
Chelating Agents - pharmacology
Citric Acid - pharmacology
Dentistry
Diphosphonates - metabolism
Edetic Acid - pharmacology
Feasibility Studies
Feasibility study
Kidney Function Tests
Osteonecrosis of the jaw
Pamidronate
Parathyroid Hormone - metabolism
Rats
Rats, Sprague-Dawley
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Summary:Highlights • This study proved the feasibility of removing bisphosphonates from bone in-vivo. • Systemic agent reduced the bisphosphonate signal from the skeleton. • This effect was due to a direct action on bone. • Local application produced a similar effect on extraction sites in the mandible. • Results suggest a new strategy to prevent BRONJ following dental procedures.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2015.09.001