Serum Uric Acid and Risk of CKD in Type 2 Diabetes

Serum uric acid may predict the onset and progression of kidney disease, but it is unclear whether uric acid is an independent risk factor for diabetic nephropathy. Our aim was to study the relationship between uric acid levels and the development of CKD components in patients with type 2 diabetes....

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Published in:Clinical journal of the American Society of Nephrology 2015-11, Vol.10 (11), p.1921-1929
Main Authors: De Cosmo, Salvatore, Viazzi, Francesca, Pacilli, Antonio, Giorda, Carlo, Ceriello, Antonio, Gentile, Sandro, Russo, Giuseppina, Rossi, Maria C, Nicolucci, Antonio, Guida, Pietro, Feig, Daniel, Johnson, Richard J, Pontremoli, Roberto
Format: Article
Language:English
Subjects:
Aged
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Female
Humans
Longitudinal Studies
Male
Middle Aged
Original
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - etiology
Risk Factors
Uric Acid - blood
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Summary:Serum uric acid may predict the onset and progression of kidney disease, but it is unclear whether uric acid is an independent risk factor for diabetic nephropathy. Our aim was to study the relationship between uric acid levels and the development of CKD components in patients with type 2 diabetes. Longitudinal study of a cohort of patients with type 2 diabetes from the database of the Italian Association of Clinical Diabetologists network. From a total of 62,830 patients attending the diabetes centers between January 1, 2004, and June 30, 2008, we considered those with baseline eGFR values ≥60 ml/min per 1.73 m2 and normal albumin excretion (n=20,142). Urinary albumin excretion, GFR, and serum uric acid were available in 13,964 patients. We assessed the association of serum uric acid quintiles with onset of CKD components by multinomial logistic regression model adjusting for potential confounders. We calculated the relative risk ratios (RRRs) for eGFR
ISSN:1555-9041
1555-905X
DOI:10.2215/cjn.03140315