Mesenchymal Stem Cell Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Recent advances in inflammatory bowel disease (IBD) therapeutics include novel medical, surgical, and endoscopic treatments. Among these, stem cell therapy is still in its infancy, although multiple studies suggest that the immunomodulatory effect of stem cell therapy may reduce inflammation and tis...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2015-11, Vol.21 (11), p.2696-2707
Main Authors: Dave, Maneesh, Mehta, Kathan, Luther, Jay, Baruah, Anushka, Dietz, Allan B, Faubion, Jr, William A
Format: Article
Language:English
Subjects:
Animals
Colitis, Ulcerative - therapy
Crohn Disease - therapy
Genetic Therapy - methods
Humans
Mesenchymal Stem Cell Transplantation
Mice
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Summary:Recent advances in inflammatory bowel disease (IBD) therapeutics include novel medical, surgical, and endoscopic treatments. Among these, stem cell therapy is still in its infancy, although multiple studies suggest that the immunomodulatory effect of stem cell therapy may reduce inflammation and tissue injury in patients with IBD. This review discusses the novel avenue of stem cell therapy and its potential role in the management of ulcerative colitis and Crohn's disease. We conducted a comprehensive literature search to identify studies examining the role of stem cell therapy (without conditioning and immunomodulatory regimens) in IBD. Taken together, these studies suggest a promising role for stem cell therapy in IBD although the substantial challenges, such as cost and inadequate/incomplete characterization of effect, limit their current use in clinical practice.
ISSN:1078-0998
1536-4844
DOI:10.1097/MIB.0000000000000543