Mad2 and p27 expression profiles in colorectal cancer and its clinical significance

To investigate the expression of tumor suppressor gene p27 and spindle checkpoint gene Mad2 and to demonstrate their expression difference in colorectal cancer and normal mucosa and to evaluate its clinical significance. Immunohistochemical staining was used for detection of expression of Mad2 and p...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2004-11, Vol.10 (21), p.3218-3220
Main Authors: Li, Gang-Qiang, Zhang, Hong-Fu
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - physiopathology
Adult
Aged
Biomarkers, Tumor
Brief Reports
Calcium-Binding Proteins - genetics
Cell Cycle Proteins - genetics
Cell Differentiation
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - physiopathology
Cyclin-Dependent Kinase Inhibitor p27
Female
Gene Expression Regulation, Neoplastic
Humans
Lymphatic Metastasis
Mad2 Proteins
Male
Middle Aged
Prognosis
Repressor Proteins
Tumor Suppressor Proteins - genetics
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Summary:To investigate the expression of tumor suppressor gene p27 and spindle checkpoint gene Mad2 and to demonstrate their expression difference in colorectal cancer and normal mucosa and to evaluate its clinical significance. Immunohistochemical staining was used for detection of expression of Mad2 and p27 in colorectal cancer and its corresponding normal mucosa. Mad2 was significantly overexpressed in colorectal cancer compared with corresponding normal mucosa (P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v10.i21.3218