Dectin-1 Exerts Dual Control in the Gut

Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacil...

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Bibliographic Details
Published in:Cell host & microbe 2015-08, Vol.18 (2), p.139-141
Main Author: Iliev, Iliyan D.
Format: Article
Language:English
Subjects:
Animals
Colitis - pathology
Colon - immunology
Colon - pathology
Lactobacillus - immunology
Lectins, C-Type - antagonists & inhibitors
Signal Transduction
T-Lymphocytes, Regulatory - immunology
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Summary:Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacilli and triggers T regulatory cell expansion in the gut. Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacilli and triggers T regulatory cell expansion in the gut.
ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2015.07.010