Wnt signaling in bone and muscle

Abstract Wnt signaling plays key roles in many aspects of development. In this review, we will briefly describe the components of signaling pathways induced by Wnt ligands and then describe the current state of research as this applies to aspects of development and disease as it relates to skeletal...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2015-11, Vol.80, p.60-66
Main Authors: Rudnicki, Michael A, Williams, Bart O
Format: Article
Language:English
Subjects:
Animals
Bone
Bone and Bones - cytology
Bone and Bones - metabolism
Frizzled
Humans
Muscle
Muscle, Skeletal - cytology
Muscle, Skeletal - metabolism
Orthopedics
Osteoblasts
Osteoblasts - cytology
Osteoblasts - metabolism
Satellite stem cells
Wnt
Wnt Proteins - metabolism
Wnt Signaling Pathway - genetics
Wnt Signaling Pathway - physiology
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Summary:Abstract Wnt signaling plays key roles in many aspects of development. In this review, we will briefly describe the components of signaling pathways induced by Wnt ligands and then describe the current state of research as this applies to aspects of development and disease as it relates to skeletal muscle and bone. We will conclude with a discussion of the parallels and differences in Wnt signaling in these two contexts and how these pathways are being (or could potentially be) targeted for therapeutic treatment of musculoskeletal diseases. This article is part of a Special Issue entitled “Muscle Bone Interactions”.
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2015.02.009