Association Between High-Sensitivity C-Reactive Protein and Total Stroke by Hypertensive Status Among Men

High-sensitivity C-reactive protein (hsCRP), a marker of systemic inflammation, may promote atherosclerosis, particularly among adults with elevated blood pressure; however, data are sparse. We examined the association between hsCRP concentrations and risk of total stroke by hypertension status (nor...

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Bibliographic Details
Published in:Journal of the American Heart Association 2015-09, Vol.4 (9), p.e002073-e002073
Main Authors: Jiménez, Monik C, Rexrode, Kathryn M, Glynn, Robert J, Ridker, Paul M, Gaziano, J Michael, Sesso, Howard D
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Blood Pressure
C-Reactive Protein - analysis
Humans
Hypertension - diagnosis
Hypertension - epidemiology
Hypertension - physiopathology
Incidence
Inflammation - blood
Inflammation - diagnosis
Inflammation - epidemiology
Inflammation Mediators - blood
Male
Middle Aged
Multivariate Analysis
Original Research
Proportional Hazards Models
Risk Assessment
Risk Factors
Stroke - blood
Stroke - diagnosis
Stroke - epidemiology
Stroke - physiopathology
Time Factors
United States - epidemiology
Up-Regulation
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Summary:High-sensitivity C-reactive protein (hsCRP), a marker of systemic inflammation, may promote atherosclerosis, particularly among adults with elevated blood pressure; however, data are sparse. We examined the association between hsCRP concentrations and risk of total stroke by hypertension status (normotension, prehypertension, and hypertension) among men in the Physicians' Health Study (PHS). Blood samples were collected (1996-1997) and assayed for hsCRP among 10 456 initially healthy men from PHS I and PHS II and followed from 1997 to 2012. Self-reported hypertension status, cardiovascular risk factors, lifestyle, and alcohol consumption were obtained from the baseline questionnaire prior to randomization in PHS II. Strokes were updated approximately annually and confirmed by medical records according to the National Survey of Stroke criteria. Multivariable Cox models were used. We observed 395 incident total strokes over 115 791 person-years. In analyses adjusted for potential confounders and stroke risk factors, clinically elevated hsCRP (>3 mg/L) was associated with a 40% significantly greater hazard of total stroke compared with hsCRP
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.115.002073