Smart Self-Assembled Hybrid Hydrogel Biomaterials

Hybrid biomaterials are systems created from components of at least two distinct classes of molecules, for example, synthetic macromolecules and proteins or peptide domains. The synergistic combination of two types of structures may produce new materials that possess unprecedented levels of structur...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2012-07, Vol.51 (30), p.7396-7417
Main Authors: Kopeček, Jindřich, Yang, Jiyuan
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
Biocompatible Materials - therapeutic use
Biomaterials
Biomedical materials
Biosensing Techniques - methods
Design engineering
Drug Delivery Systems - methods
Genetic Engineering - methods
Humans
hybrid biomaterials
Hybrid systems
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism
Hydrogel, Polyethylene Glycol Dimethacrylate - therapeutic use
Hydrogels
Macromolecules
Models, Molecular
molecular recognition
Molecular Sequence Data
Nanomedicine
Peptides
Peptides - chemistry
Peptides - genetics
Peptides - metabolism
Peptides - therapeutic use
Protein Conformation
protein structures
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Proteins - therapeutic use
Self assembly
Similarity
Surgical implants
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Description
Summary:Hybrid biomaterials are systems created from components of at least two distinct classes of molecules, for example, synthetic macromolecules and proteins or peptide domains. The synergistic combination of two types of structures may produce new materials that possess unprecedented levels of structural organization and novel properties. This Review focuses on biorecognition‐driven self‐assembly of hybrid macromolecules into functional hydrogel biomaterials. First, basic rules that govern the secondary structure of peptides are discussed, and then approaches to the specific design of hybrid systems with tailor‐made properties are evaluated, followed by a discussion on the similarity of design principles of biomaterials and macromolecular therapeutics. Finally, the future of the field is briefly outlined. Hybrid biomaterials: The self‐assembly of macromolecules composed of two or more distinct classes of molecules by biorecognition results in new materials with high degree of organization. This Review focuses on synthetic macromolecules and peptide motifs. Approaches to the design of hybrid systems are evaluated, followed by a discussion on similarity of designs of biomaterials and nanomedicines.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201201040