Environmental exposure to organochlorine pesticides and deficits in cochlear status in children

The aim of this study was to examine the hypothesis that organochlorine pesticides (OCPs), hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p′-DDT) and its metabolite 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p′- DDE) are ototoxic t...

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Bibliographic Details
Published in:Environmental science and pollution research international 2015-10, Vol.22 (19), p.14570-14578
Main Authors: Sisto, Renata, Moleti, Arturo, Palkovičová Murínová, Ľubica, Wimmerová, Soňa, Lancz, Kinga, Tihányi, Juraj, Čonka, Kamil, Šovčíková, Eva, Hertz-Picciotto, Irva, Jusko, Todd A., Trnovec, Tomáš
Format: Article
Language:English
Subjects:
12th IHPA Forum and selected studies on POPs
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Child
Cochlea - drug effects
Cochlea - physiology
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Exposure - analysis
Environmental Health
Environmental science
Female
Health sciences
Hearing loss
Homeostasis
Humans
Hydrocarbons, Chlorinated - analysis
Hydrocarbons, Chlorinated - toxicity
Hypotheses
Male
Mothers
PCB
Pesticides
Pesticides - analysis
Pesticides - toxicity
Pollutants
Polybrominated diphenyl ethers
Polychlorinated biphenyls
Public health
Studies
Thyroid gland
Toxicity
Waste Water Technology
Water Management
Water Pollution Control
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Summary:The aim of this study was to examine the hypothesis that organochlorine pesticides (OCPs), hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p′-DDT) and its metabolite 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p′- DDE) are ototoxic to humans. A multivariate general linear model was designed, in which the statistical relation between blood serum concentrations of HCB, β-HCH, p,p′-DDT, or p,p′-DDE at different ages (at birth, 6, 16, and 45 months) and the distortion product otoacoustic emissions (DPOAEs) was treated as multivariate outcome variables. Polychlorinated biphenyl (PCB) congeners and OCPs were strongly correlated in serum of children from our cohort. To ascertain that the association between DPOAEs at a given frequency and concentration of a pesticide is not influenced by PCBs or other OCP also present in serum, we calculated benchmark concentrations (BMCs) relating DPOAEs to a serum pesticide alone and in presence of confounding PCB-153 or other OCPs. We found that BMCs relating DPOAEs to serum pesticides are not affected by confounders. DPOAE amplitudes were associated with serum OCPs at all investigated time intervals, however, in a positive way with prenatal exposure and in a negative way with all postnatal exposures. We observed tonotopicity in the association of pesticides with amplitude of DPOAEs as its strength was frequency dependent. We conclude that exposure to OCPs in infancy at environmental concentrations may be associated with hearing deficits.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-015-4690-5