Diagnostic outcome of ureteroscopy in urothelial carcinoma of the upper urinary tract: Incidence of later cancer detection and its risk factors after the first examination

To determine the incidence of later cancer detection and its risk factors after the first diagnostic ureteroscopy. One hundred and sixty-six patients undergoing diagnostic ureteroscopy based on the suspicion of urothelial carcinoma of the upper urinary tract (UC of the UUT) between 1995 and 2012 wer...

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Bibliographic Details
Published in:BMC urology 2015-09, Vol.15 (1), p.92-92, Article 92
Main Authors: Murahashi, Norihiro, Abe, Takashige, Shinohara, Nobuo, Murai, Sachiyo, Harabayashi, Toru, Sazawa, Ataru, Maruyama, Satoru, Tsuchiya, Kunihiko, Miyajima, Naoto, Hatanaka, Kanako, Nonomura, Katsuya
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - surgery
Female
Humans
Incidence
Japan - epidemiology
Male
Middle Aged
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - prevention & control
Reproducibility of Results
Retrospective Studies
Risk Factors
Sensitivity and Specificity
Survival Rate
Ureteroscopy - mortality
Ureteroscopy - statistics & numerical data
Urologic Neoplasms - pathology
Urologic Neoplasms - surgery
Young Adult
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Summary:To determine the incidence of later cancer detection and its risk factors after the first diagnostic ureteroscopy. One hundred and sixty-six patients undergoing diagnostic ureteroscopy based on the suspicion of urothelial carcinoma of the upper urinary tract (UC of the UUT) between 1995 and 2012 were included. We examined the diagnostic outcome of the initial ureteroscopy. Thereafter, we collected follow-up data on patients who had not been diagnosed with UC of the UUT at the first examination, and evaluated the incidence of later cancer detection and its risk factors using Cox hazard models. Of the 166 patients, 76 (45.8%) were diagnosed with UC of the UUT at the first diagnostic ureteroscopy. The remaining 90 (54.2%) were diagnosed with other malignancies (n = 22), non-malignant disorders (n = 18), or without disorders (n = 50). Of these 90 patients, follow-up data were available in 65 patients (median: 41 months, range: 3-170). During the follow-up, carcinoma was detected in 6 patients (6/65, 9.2%) at a median of 43.5 months (range: 10-59). Episodes of gross hematuria (p = 0.0048) and abnormal cytological findings (p = 0.0335) during the follow-up and a male sex (p = 0.0316) were adverse risk factors. Later cancer detection of UC of the UUT was not uncommon after the first examination. The risk analysis revealed the aforementioned characteristics.
ISSN:1471-2490
1471-2490
DOI:10.1186/s12894-015-0086-6