High-Sensitivity Cardiac Troponin T and Risk of Hypertension

BACKGROUND—The diagnosis of hypertension is often preceded by cardiac structural abnormalities. Thus, we assessed whether high-sensitivity cardiac troponin T (hs-cTnT), a marker of subclinical myocardial damage, can identify individuals at risk for hypertension or left ventricular hypertrophy. METHO...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2015-09, Vol.132 (9), p.825-833
Main Authors: McEvoy, John W, Chen, Yuan, Nambi, Vijay, Ballantyne, Christie M, Sharrett, A Richey, Appel, Lawrence J, Post, Wendy S, Blumenthal, Roger S, Matsushita, Kunihiro, Selvin, Elizabeth
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Cohort Studies
Female
Humans
Hypertension - blood
Hypertension - diagnosis
Hypertension - epidemiology
Male
Middle Aged
Prospective Studies
Risk Factors
Troponin T - blood
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Summary:BACKGROUND—The diagnosis of hypertension is often preceded by cardiac structural abnormalities. Thus, we assessed whether high-sensitivity cardiac troponin T (hs-cTnT), a marker of subclinical myocardial damage, can identify individuals at risk for hypertension or left ventricular hypertrophy. METHODS AND RESULTS—We studied 6516 Atherosclerosis Risk in Communities (ARIC) Study participants who were free of prevalent hypertension and cardiovascular disease at baseline (1990–1992). We examined the association of baseline hs-cTnT categories with incident diagnosed hypertension (defined by self-report of a diagnosis or medication use during a maximum of 19.9 years of follow-up) and with incident visit-based hypertension (defined by self-report, medication use, or measured blood pressure >140/90 mm Hg over 6 years). Relative to hs-cTnT
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.114.014364