Nuclear scaffold attachment sites in the human globin gene complexes

In an analysis of a 90‐kb region around the human beta‐globin gene complex we have identified at least eight sites of attachment to the nuclear scaffold (SARs). While these have many potential functions, there appears to be a particular association with sequences important in the regulation of the c...

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Bibliographic Details
Published in:	The EMBO journal 1988-11, Vol.7 (11), p.3337-3344
Main Authors:	Jarman, A. P., Higgs, D. R.
Format:	Article
Language:	eng
Subjects:	Binding Sites Biological and medical sciences Blotting, Southern Cell Nucleus - metabolism DNA - analysis DNA - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Globins - genetics Humans Molecular and cellular biology Molecular genetics Multigene Family Nucleic Acid Hybridization Restriction Mapping
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Summary:	In an analysis of a 90‐kb region around the human beta‐globin gene complex we have identified at least eight sites of attachment to the nuclear scaffold (SARs). While these have many potential functions, there appears to be a particular association with sequences important in the regulation of the complex. Two SARs are close to the known enhancer‐like elements of the beta‐globin gene. SARs flanking the complex co‐habit with the boundaries of the putative beta‐like globin gene regulatory domain. In contrast, we have detected no SARs within a 140‐kb region of the human alpha‐globin gene complex. If SARs play a role in the regulation of gene expression then this structural difference would imply a difference in the regulation of the two complexes.
ISSN:	0261-4189 1460-2075