Loading…
NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility
Intracellular pattern-recognition receptors NOD1 and NOD2 are capable of sensing common structural units of bacterial walls. Recognition triggers specific immune signalling pathways and leads to pro-inflammatory cytokine upregulation and adequate immune response. We investigated whether two function...
Saved in:
| Published in: | Pathogens and disease 2015-02, Vol.73 (1), p.1-9 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c514t-f9f05713bfa6198b6f5b710815da889a61b8bb7808a0cad10ad212ae9023ce053 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c514t-f9f05713bfa6198b6f5b710815da889a61b8bb7808a0cad10ad212ae9023ce053 |
| container_end_page | 9 |
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Pathogens and disease |
| container_volume | 73 |
| creator | Branković, Ivan van Ess, Eleanne F. Noz, Marlies P. Wiericx, Wilhelmina (Anke) J. Spaargaren, Joke Morré, Servaas A. Ouburg, Sander |
| description | Intracellular pattern-recognition receptors NOD1 and NOD2 are capable of sensing common structural units of bacterial walls. Recognition triggers specific immune signalling pathways and leads to pro-inflammatory cytokine upregulation and adequate immune response. We investigated whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) Chlamydia trachomatis infection in 807 Dutch Caucasian women. A significant association of the NOD1 +32656 GG insertion variant with protection against infection with C. trachomatis has been detected [p: 0.0057; OR: 0.52]. When comparing C. trachomatis-positive women without symptoms to C. trachomatis-positive women with symptoms, and to C. trachomatis-positive women with TFI, we observed an increasing trend in carriage of the GG allele [Ptrend: 0.0003]. NOD2 1007fs failed to reveal an association. We hypothesize that the underlying mechanism might be a functional effect of the GG insertion on IFN-beta-dependent regulation of immune response in the genital tract. The research is part of an ongoing effort of identifying key polymorphisms that determine the risk of TFI and effectively translating them into the clinical setting for the purpose of optimizing diagnostic management of women at risk for developing TFI.
Investigation of whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) C. trachomatis infection in 807 Dutch Caucasian women. |
| doi_str_mv | 10.1093/femspd/ftu028 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4542905</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/femspd/ftu028</oup_id><sourcerecordid>1672608528</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-f9f05713bfa6198b6f5b710815da889a61b8bb7808a0cad10ad212ae9023ce053</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EolXbI1dkiQuXUNuJE-eChLZ8SVV7aSVu1sSxiYsTB38g7Zk_jne3lMIFX8aaeebVzLwIvaDkDSV9fW70HNfx3KRMmHiCjhlp-qqt2Zenj_5H6CzGO1Ke4FR07XN0xLjgDSHtMfp5dX1BsV2w8ksKEBNOHpccwyYvKlm_gMOrd9vZh3WycS6scVkvSuPN5GDejhZw6VSTnyHZuKvrfSOGZcRp0jjY-A17g1MeipgBlXzYYyFZZ9P2FD0z4KI-u48n6PbD-5vNp-ry-uPnzbvLSnHapMr0hvCO1oOBlvZiaA0fOkoE5SMI0ZfkIIahE0QAUTBSAiOjDHRPWK004fUJenvQXfMw61Hp3cZOrsHOELbSg5V_VxY7ya_-h2x4w_q9wOt7geC_Zx2TnG1U2jlYtM9R0rZjbbkyEwV99Q9653Mox4yS1YT3pGNiR1UHSgUfY9DmYRhK5M5heXBYHhwu_MvHGzzQv_38M6HP63-0fgG0RrRf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2305907288</pqid></control><display><type>article</type><title>NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility</title><source>PubMed (Medline)</source><source>Oxford Academic</source><creator>Branković, Ivan ; van Ess, Eleanne F. ; Noz, Marlies P. ; Wiericx, Wilhelmina (Anke) J. ; Spaargaren, Joke ; Morré, Servaas A. ; Ouburg, Sander</creator><creatorcontrib>Branković, Ivan ; van Ess, Eleanne F. ; Noz, Marlies P. ; Wiericx, Wilhelmina (Anke) J. ; Spaargaren, Joke ; Morré, Servaas A. ; Ouburg, Sander</creatorcontrib><description>Intracellular pattern-recognition receptors NOD1 and NOD2 are capable of sensing common structural units of bacterial walls. Recognition triggers specific immune signalling pathways and leads to pro-inflammatory cytokine upregulation and adequate immune response. We investigated whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) Chlamydia trachomatis infection in 807 Dutch Caucasian women. A significant association of the NOD1 +32656 GG insertion variant with protection against infection with C. trachomatis has been detected [p: 0.0057; OR: 0.52]. When comparing C. trachomatis-positive women without symptoms to C. trachomatis-positive women with symptoms, and to C. trachomatis-positive women with TFI, we observed an increasing trend in carriage of the GG allele [Ptrend: 0.0003]. NOD2 1007fs failed to reveal an association. We hypothesize that the underlying mechanism might be a functional effect of the GG insertion on IFN-beta-dependent regulation of immune response in the genital tract. The research is part of an ongoing effort of identifying key polymorphisms that determine the risk of TFI and effectively translating them into the clinical setting for the purpose of optimizing diagnostic management of women at risk for developing TFI.
Investigation of whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) C. trachomatis infection in 807 Dutch Caucasian women.</description><identifier>ISSN: 2049-632X</identifier><identifier>EISSN: 2049-632X</identifier><identifier>DOI: 10.1093/femspd/ftu028</identifier><identifier>PMID: 25854006</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Chlamydia ; Chlamydia Infections - complications ; Chlamydia Infections - immunology ; Chlamydia trachomatis ; Chlamydia trachomatis - immunology ; Diagnostic systems ; Female ; Fertility ; Genetic Predisposition to Disease ; Genital tract ; Health risks ; Humans ; Immune response ; Immune system ; Infections ; Infertility ; Infertility - epidemiology ; Inflammation ; Insertion ; Netherlands ; Nod1 protein ; Nod1 Signaling Adaptor Protein - metabolism ; NOD2 protein ; Nod2 Signaling Adaptor Protein - metabolism ; Pattern recognition ; Polymorphism ; Polymorphism, Genetic ; Receptors ; Retrospective Studies ; Risk ; Risk Assessment ; Risk factors ; Risk management ; Sexually transmitted diseases ; Signal transduction ; STD ; Young Adult ; β-Interferon</subject><ispartof>Pathogens and disease, 2015-02, Vol.73 (1), p.1-9</ispartof><rights>The Author 2015. Published by Oxford University Press on behalf of FEMS. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com . 2015</rights><rights>The Author 2015. Published by Oxford University Press on behalf of FEMS. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>The Author 2015. Published by Oxford University Press on behalf of FEMS. All rights reserved. For permissions, please e-mail: . 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-f9f05713bfa6198b6f5b710815da889a61b8bb7808a0cad10ad212ae9023ce053</citedby><cites>FETCH-LOGICAL-c514t-f9f05713bfa6198b6f5b710815da889a61b8bb7808a0cad10ad212ae9023ce053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542905/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542905/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,1591,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25854006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Branković, Ivan</creatorcontrib><creatorcontrib>van Ess, Eleanne F.</creatorcontrib><creatorcontrib>Noz, Marlies P.</creatorcontrib><creatorcontrib>Wiericx, Wilhelmina (Anke) J.</creatorcontrib><creatorcontrib>Spaargaren, Joke</creatorcontrib><creatorcontrib>Morré, Servaas A.</creatorcontrib><creatorcontrib>Ouburg, Sander</creatorcontrib><title>NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility</title><title>Pathogens and disease</title><addtitle>Pathog Dis</addtitle><description>Intracellular pattern-recognition receptors NOD1 and NOD2 are capable of sensing common structural units of bacterial walls. Recognition triggers specific immune signalling pathways and leads to pro-inflammatory cytokine upregulation and adequate immune response. We investigated whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) Chlamydia trachomatis infection in 807 Dutch Caucasian women. A significant association of the NOD1 +32656 GG insertion variant with protection against infection with C. trachomatis has been detected [p: 0.0057; OR: 0.52]. When comparing C. trachomatis-positive women without symptoms to C. trachomatis-positive women with symptoms, and to C. trachomatis-positive women with TFI, we observed an increasing trend in carriage of the GG allele [Ptrend: 0.0003]. NOD2 1007fs failed to reveal an association. We hypothesize that the underlying mechanism might be a functional effect of the GG insertion on IFN-beta-dependent regulation of immune response in the genital tract. The research is part of an ongoing effort of identifying key polymorphisms that determine the risk of TFI and effectively translating them into the clinical setting for the purpose of optimizing diagnostic management of women at risk for developing TFI.
Investigation of whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) C. trachomatis infection in 807 Dutch Caucasian women.</description><subject>Adult</subject><subject>Chlamydia</subject><subject>Chlamydia Infections - complications</subject><subject>Chlamydia Infections - immunology</subject><subject>Chlamydia trachomatis</subject><subject>Chlamydia trachomatis - immunology</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Fertility</subject><subject>Genetic Predisposition to Disease</subject><subject>Genital tract</subject><subject>Health risks</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Infections</subject><subject>Infertility</subject><subject>Infertility - epidemiology</subject><subject>Inflammation</subject><subject>Insertion</subject><subject>Netherlands</subject><subject>Nod1 protein</subject><subject>Nod1 Signaling Adaptor Protein - metabolism</subject><subject>NOD2 protein</subject><subject>Nod2 Signaling Adaptor Protein - metabolism</subject><subject>Pattern recognition</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Receptors</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>Risk management</subject><subject>Sexually transmitted diseases</subject><subject>Signal transduction</subject><subject>STD</subject><subject>Young Adult</subject><subject>β-Interferon</subject><issn>2049-632X</issn><issn>2049-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EolXbI1dkiQuXUNuJE-eChLZ8SVV7aSVu1sSxiYsTB38g7Zk_jne3lMIFX8aaeebVzLwIvaDkDSV9fW70HNfx3KRMmHiCjhlp-qqt2Zenj_5H6CzGO1Ke4FR07XN0xLjgDSHtMfp5dX1BsV2w8ksKEBNOHpccwyYvKlm_gMOrd9vZh3WycS6scVkvSuPN5GDejhZw6VSTnyHZuKvrfSOGZcRp0jjY-A17g1MeipgBlXzYYyFZZ9P2FD0z4KI-u48n6PbD-5vNp-ry-uPnzbvLSnHapMr0hvCO1oOBlvZiaA0fOkoE5SMI0ZfkIIahE0QAUTBSAiOjDHRPWK004fUJenvQXfMw61Hp3cZOrsHOELbSg5V_VxY7ya_-h2x4w_q9wOt7geC_Zx2TnG1U2jlYtM9R0rZjbbkyEwV99Q9653Mox4yS1YT3pGNiR1UHSgUfY9DmYRhK5M5heXBYHhwu_MvHGzzQv_38M6HP63-0fgG0RrRf</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Branković, Ivan</creator><creator>van Ess, Eleanne F.</creator><creator>Noz, Marlies P.</creator><creator>Wiericx, Wilhelmina (Anke) J.</creator><creator>Spaargaren, Joke</creator><creator>Morré, Servaas A.</creator><creator>Ouburg, Sander</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility</title><author>Branković, Ivan ; van Ess, Eleanne F. ; Noz, Marlies P. ; Wiericx, Wilhelmina (Anke) J. ; Spaargaren, Joke ; Morré, Servaas A. ; Ouburg, Sander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-f9f05713bfa6198b6f5b710815da889a61b8bb7808a0cad10ad212ae9023ce053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Chlamydia</topic><topic>Chlamydia Infections - complications</topic><topic>Chlamydia Infections - immunology</topic><topic>Chlamydia trachomatis</topic><topic>Chlamydia trachomatis - immunology</topic><topic>Diagnostic systems</topic><topic>Female</topic><topic>Fertility</topic><topic>Genetic Predisposition to Disease</topic><topic>Genital tract</topic><topic>Health risks</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Infections</topic><topic>Infertility</topic><topic>Infertility - epidemiology</topic><topic>Inflammation</topic><topic>Insertion</topic><topic>Netherlands</topic><topic>Nod1 protein</topic><topic>Nod1 Signaling Adaptor Protein - metabolism</topic><topic>NOD2 protein</topic><topic>Nod2 Signaling Adaptor Protein - metabolism</topic><topic>Pattern recognition</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Receptors</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>Risk management</topic><topic>Sexually transmitted diseases</topic><topic>Signal transduction</topic><topic>STD</topic><topic>Young Adult</topic><topic>β-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Branković, Ivan</creatorcontrib><creatorcontrib>van Ess, Eleanne F.</creatorcontrib><creatorcontrib>Noz, Marlies P.</creatorcontrib><creatorcontrib>Wiericx, Wilhelmina (Anke) J.</creatorcontrib><creatorcontrib>Spaargaren, Joke</creatorcontrib><creatorcontrib>Morré, Servaas A.</creatorcontrib><creatorcontrib>Ouburg, Sander</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pathogens and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Branković, Ivan</au><au>van Ess, Eleanne F.</au><au>Noz, Marlies P.</au><au>Wiericx, Wilhelmina (Anke) J.</au><au>Spaargaren, Joke</au><au>Morré, Servaas A.</au><au>Ouburg, Sander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility</atitle><jtitle>Pathogens and disease</jtitle><addtitle>Pathog Dis</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>73</volume><issue>1</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2049-632X</issn><eissn>2049-632X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Intracellular pattern-recognition receptors NOD1 and NOD2 are capable of sensing common structural units of bacterial walls. Recognition triggers specific immune signalling pathways and leads to pro-inflammatory cytokine upregulation and adequate immune response. We investigated whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) Chlamydia trachomatis infection in 807 Dutch Caucasian women. A significant association of the NOD1 +32656 GG insertion variant with protection against infection with C. trachomatis has been detected [p: 0.0057; OR: 0.52]. When comparing C. trachomatis-positive women without symptoms to C. trachomatis-positive women with symptoms, and to C. trachomatis-positive women with TFI, we observed an increasing trend in carriage of the GG allele [Ptrend: 0.0003]. NOD2 1007fs failed to reveal an association. We hypothesize that the underlying mechanism might be a functional effect of the GG insertion on IFN-beta-dependent regulation of immune response in the genital tract. The research is part of an ongoing effort of identifying key polymorphisms that determine the risk of TFI and effectively translating them into the clinical setting for the purpose of optimizing diagnostic management of women at risk for developing TFI.
Investigation of whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) C. trachomatis infection in 807 Dutch Caucasian women.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>25854006</pmid><doi>10.1093/femspd/ftu028</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2049-632X |
| ispartof | Pathogens and disease, 2015-02, Vol.73 (1), p.1-9 |
| issn | 2049-632X 2049-632X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4542905 |
| source | PubMed (Medline); Oxford Academic |
| subjects | Adult Chlamydia Chlamydia Infections - complications Chlamydia Infections - immunology Chlamydia trachomatis Chlamydia trachomatis - immunology Diagnostic systems Female Fertility Genetic Predisposition to Disease Genital tract Health risks Humans Immune response Immune system Infections Infertility Infertility - epidemiology Inflammation Insertion Netherlands Nod1 protein Nod1 Signaling Adaptor Protein - metabolism NOD2 protein Nod2 Signaling Adaptor Protein - metabolism Pattern recognition Polymorphism Polymorphism, Genetic Receptors Retrospective Studies Risk Risk Assessment Risk factors Risk management Sexually transmitted diseases Signal transduction STD Young Adult β-Interferon |
| title | NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T23%3A13%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=NOD1%20in%20contrast%20to%20NOD2%20functional%20polymorphism%20influence%20Chlamydia%20trachomatis%20infection%20and%20the%20risk%20of%20tubal%20factor%20infertility&rft.jtitle=Pathogens%20and%20disease&rft.au=Brankovi%C4%87,%20Ivan&rft.date=2015-02-01&rft.volume=73&rft.issue=1&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=2049-632X&rft.eissn=2049-632X&rft_id=info:doi/10.1093/femspd/ftu028&rft_dat=%3Cproquest_pubme%3E1672608528%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c514t-f9f05713bfa6198b6f5b710815da889a61b8bb7808a0cad10ad212ae9023ce053%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2305907288&rft_id=info:pmid/25854006&rft_oup_id=10.1093/femspd/ftu028&rfr_iscdi=true |