NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility

Intracellular pattern-recognition receptors NOD1 and NOD2 are capable of sensing common structural units of bacterial walls. Recognition triggers specific immune signalling pathways and leads to pro-inflammatory cytokine upregulation and adequate immune response. We investigated whether two function...

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Bibliographic Details
Published in:Pathogens and disease 2015-02, Vol.73 (1), p.1-9
Main Authors: Branković, Ivan, van Ess, Eleanne F., Noz, Marlies P., Wiericx, Wilhelmina (Anke) J., Spaargaren, Joke, Morré, Servaas A., Ouburg, Sander
Format: Article
Language:English
Subjects:
Adult
Chlamydia
Chlamydia Infections - complications
Chlamydia Infections - immunology
Chlamydia trachomatis
Chlamydia trachomatis - immunology
Diagnostic systems
Female
Fertility
Genetic Predisposition to Disease
Genital tract
Health risks
Humans
Immune response
Immune system
Infections
Infertility
Infertility - epidemiology
Inflammation
Insertion
Netherlands
Nod1 protein
Nod1 Signaling Adaptor Protein - metabolism
NOD2 protein
Nod2 Signaling Adaptor Protein - metabolism
Pattern recognition
Polymorphism
Polymorphism, Genetic
Receptors
Retrospective Studies
Risk
Risk Assessment
Risk factors
Risk management
Sexually transmitted diseases
Signal transduction
STD
Young Adult
β-Interferon
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Summary:Intracellular pattern-recognition receptors NOD1 and NOD2 are capable of sensing common structural units of bacterial walls. Recognition triggers specific immune signalling pathways and leads to pro-inflammatory cytokine upregulation and adequate immune response. We investigated whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) Chlamydia trachomatis infection in 807 Dutch Caucasian women. A significant association of the NOD1 +32656 GG insertion variant with protection against infection with C. trachomatis has been detected [p: 0.0057; OR: 0.52]. When comparing C. trachomatis-positive women without symptoms to C. trachomatis-positive women with symptoms, and to C. trachomatis-positive women with TFI, we observed an increasing trend in carriage of the GG allele [Ptrend: 0.0003]. NOD2 1007fs failed to reveal an association. We hypothesize that the underlying mechanism might be a functional effect of the GG insertion on IFN-beta-dependent regulation of immune response in the genital tract. The research is part of an ongoing effort of identifying key polymorphisms that determine the risk of TFI and effectively translating them into the clinical setting for the purpose of optimizing diagnostic management of women at risk for developing TFI. Investigation of whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) C. trachomatis infection in 807 Dutch Caucasian women.
ISSN:2049-632X
2049-632X
DOI:10.1093/femspd/ftu028