Catechol-Functionalized Synthetic Polymer as a Dental Adhesive to Contaminated Dentin Surface for a Composite Restoration

This study reports a synthetic polymer functionalized with catechol groups as dental adhesives. We hypothesize that a catechol-functionalized polymer functions as a dental adhesive for wet dentin surfaces, potentially eliminating the complications associated with saliva contamination. We prepared a...

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Bibliographic Details
Published in:Biomacromolecules 2015-08, Vol.16 (8), p.2265-2275
Main Authors: Lee, Sang-Bae, González-Cabezas, Carlos, Kim, Kwang-Mahn, Kim, Kyoung-Nam, Kuroda, Kenichi
Format: Article
Language:English
Subjects:
Catechols - chemical synthesis
Catechols - chemistry
Composite Resins - chemical synthesis
Composite Resins - chemistry
Dental Bonding
Dental Cements - chemical synthesis
Dental Cements - chemistry
Dentin - chemistry
Humans
Materials Testing
Methacrylates - chemistry
Polymers - chemical synthesis
Polymers - chemistry
Surface Properties
Tensile Strength
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Summary:This study reports a synthetic polymer functionalized with catechol groups as dental adhesives. We hypothesize that a catechol-functionalized polymer functions as a dental adhesive for wet dentin surfaces, potentially eliminating the complications associated with saliva contamination. We prepared a random copolymer containing catechol and methoxyethyl groups in the side chains. The mechanical and adhesive properties of the polymer to dentin surface in the presence of water and salivary components were determined. It was found that the new polymer combined with an Fe3+ additive improved bond strength of a commercial dental adhesive to artificial saliva contaminated dentin surface as compared to a control sample without the polymer. Histological analysis of the bonding structures showed no leakage pattern, probably due to the formation of Fe–catechol complexes, which reinforce the bonding structures. Cytotoxicity test showed that the polymers did not inhibit human gingival fibroblast cells proliferation. Results from this study suggest a potential to reduce failure of dental restorations due to saliva contamination using catechol-functionalized polymers as dental adhesives.
ISSN:1525-7797
1526-4602
DOI:10.1021/acs.biomac.5b00451