Longitudinal Forced Vital Capacity Monitoring as a Prognostic Adjunct after Lung Transplantation

After lung transplantation, spirometric values are routinely followed to assess graft function. FEV1 is used to characterize chronic allograft dysfunction, whereas the course of FVC change has been less acknowledged and rarely used. To better understand the temporal relationship and prognostic abili...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2015-07, Vol.192 (2), p.209-218
Main Authors: Belloli, Elizabeth A, Wang, Xin, Murray, Susan, Forrester, Ginia, Weyhing, Adrian, Lin, Jules, Ojo, Tammy, Lama, Vibha N
Format: Article
Language:English
Subjects:
Adult
Female
Forced Expiratory Volume - physiology
Graft Rejection
Humans
Longitudinal Studies
Lung - physiopathology
Lung Transplantation
Male
Middle Aged
Original
Postoperative Complications - diagnosis
Postoperative Complications - physiopathology
Spirometry - methods
Vital Capacity - physiology
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Summary:After lung transplantation, spirometric values are routinely followed to assess graft function. FEV1 is used to characterize chronic allograft dysfunction, whereas the course of FVC change has been less acknowledged and rarely used. To better understand the temporal relationship and prognostic ability of FEV1 and FVC decline after lung transplantation. Serial FEV1 and FVC values were studied among 205 bilateral lung transplant recipients. Different decline patterns were characterized and evaluated for prognostic value via restricted mean modeling of mortality and times to other pertinent events. Baseline FEV1 was achieved earlier than baseline FVC (median, 296 vs. 378 d; P 
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201501-0174oc