Obstructive Sleep Apnea is Related to Impaired Cognitive and Functional Status after Stroke

Obstructive sleep apnea (OSA) is a common sleep disorder in stroke patients and is associated with prolonged hospitalization, decreased functional outcome, and recurrent stroke. Research on the effect of OSA on cognitive functioning following stroke is scarce. The primary objective of this study was...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2015-09, Vol.38 (9), p.1431-1437
Main Authors: Aaronson, Justine A, van Bennekom, Coen A M, Hofman, Winni F, van Bezeij, Tijs, van den Aardweg, Joost G, Groet, Erny, Kylstra, Wytske A, Schmand, Ben
Format: Article
Language:English
Subjects:
Adult
Aged
Body Mass Index
Case-Control Studies
Cognition
Cognition Disorders - complications
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Executive Function
Female
Hospitalization - statistics & numerical data
Humans
Intelligence
Male
Middle Aged
Obstructive Sleep Apnea and Stroke Outcome
Prognosis
Psychomotor Performance
Sleep
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - physiopathology
Sleep Apnea, Obstructive - psychology
Stroke - complications
Stroke - physiopathology
Stroke - psychology
Stroke Rehabilitation
Young Adult
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Summary:Obstructive sleep apnea (OSA) is a common sleep disorder in stroke patients and is associated with prolonged hospitalization, decreased functional outcome, and recurrent stroke. Research on the effect of OSA on cognitive functioning following stroke is scarce. The primary objective of this study was to compare stroke patients with and without OSA on cognitive and functional status upon admission to inpatient rehabilitation. Case-control study. 147 stroke patients admitted to a neurorehabilitation unit. N/A. All patients underwent sleep examination for diagnosis of OSA. We assessed cognitive status by neuropsychological examination and functional status by two neurological scales and a measure of functional independence. We included 80 stroke patients with OSA and 67 stroke patients without OSA. OSA patients were older and had a higher body mass index than patients without OSA. OSA patients performed worse on tests of attention, executive functioning, visuoperception, psychomotor ability, and intelligence than those without OSA. No differences were found for vigilance, memory, and language. OSA patients had a worse neurological status, lower functional independence scores, and a longer period of hospitalization in the neurorehabilitation unit than the patients without OSA. OSA status was not associated with stroke type or classification. Obstructive sleep apnea (OSA) is associated with a lower cognitive and functional status in patients admitted for stroke rehabilitation. This underlines the importance of OSA as a probable prognostic factor, and calls for well-designed randomized controlled trials to study its treatability.
ISSN:0161-8105
1550-9109
DOI:10.5665/sleep.4984