Novel Biomarkers of Cardiac Stress, Cardiovascular Dysfunction, and Outcomes in HIV-Infected Individuals

Abstract Objectives This study sought to determine whether biomarkers ST2, growth differentiation factor (GDF)-15, N-terminal pro–B-type natriuretic peptide (NT-proBNP), and high-sensitivity troponin I are elevated in patients infected with human immunodeficiency virus (HIV) and are associated with...

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Bibliographic Details
Published in:JACC. Heart failure 2015-08, Vol.3 (8), p.591-599
Main Authors: Secemsky, Eric A., MD, Scherzer, Rebecca, PhD, Nitta, Elaine, MPH, Wu, Alan H.B., PhD, Lange, David C., MD, Deeks, Steven G., MD, Martin, Jeffrey N., MD, Snider, James, PhD, Ganz, Peter, MD, Hsue, Priscilla Y., MD
Format: Article
Language:English
Subjects:
Adult
biomarkers
Biomarkers - blood
Cardiovascular
cardiovascular dysfunction
Cohort Studies
death
Echocardiography
Female
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure, Diastolic - blood
Heart Failure, Diastolic - diagnosis
HIV
HIV Infections - blood
HIV Infections - diagnosis
Humans
Hypertension, Pulmonary - blood
Hypertension, Pulmonary - diagnosis
Interleukin-1 Receptor-Like 1 Protein
Male
Middle Aged
mortality
Natriuretic Peptide, Brain - blood
Outcome Assessment (Health Care)
Peptide Fragments - blood
Predictive Value of Tests
Receptors, Cell Surface - blood
Reference Values
Survival Rate
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Summary:Abstract Objectives This study sought to determine whether biomarkers ST2, growth differentiation factor (GDF)-15, N-terminal pro–B-type natriuretic peptide (NT-proBNP), and high-sensitivity troponin I are elevated in patients infected with human immunodeficiency virus (HIV) and are associated with cardiovascular dysfunction and all-cause mortality. Background HIV-infected patients have high rates of cardiovascular disease. Markers of myocardial stress may identify at-risk patients and provide additional prognostic information. Methods Biomarkers and echocardiograms were assessed in 332 HIV-infected patients and 50 age- and sex-matched control subjects. Left ventricular systolic dysfunction was defined as ejection fraction 
ISSN:2213-1779
2213-1787
DOI:10.1016/j.jchf.2015.03.007