Impaired Recognition and Regulation of Disgust Is Associated with Distinct but Partially Overlapping Patterns of Decreased Gray Matter Volume in the Ventroanterior Insula

Abstract Background The ventroanterior insula is implicated in the experience, expression, and recognition of disgust; however, whether this brain region is required for recognizing disgust or regulating disgusting behaviors remains unknown. Methods We examined the brain correlates of the presence o...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2015-10, Vol.78 (7), p.505-514
Main Authors: Woolley, Josh D, Strobl, Eric V, Sturm, Virginia E, Shany-Ur, Tal, Poorzand, Pardis, Grossman, Scott, Nguyen, Lauren, Eckart, Janet A, Levenson, Robert W, Seeley, William W, Miller, Bruce L, Rankin, Katherine P
Format: Article
Language:English
Subjects:
Aged
Cerebral Cortex - pathology
Disgust
Emotion recognition
Emotions - physiology
Facial Recognition - physiology
Family
Female
Frontotemporal dementia
Frontotemporal Dementia - pathology
Frontotemporal Dementia - psychology
Gray Matter - pathology
Humans
Image Processing, Computer-Assisted
Insula
Magnetic Resonance Imaging
Male
Middle Aged
Neurodegeneration
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - psychology
Neuropsychological Tests
Organ Size
Psychiatry
Recognition (Psychology) - physiology
Retrospective Studies
Voxel-based morphometry
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Summary:Abstract Background The ventroanterior insula is implicated in the experience, expression, and recognition of disgust; however, whether this brain region is required for recognizing disgust or regulating disgusting behaviors remains unknown. Methods We examined the brain correlates of the presence of disgusting behavior and impaired recognition of disgust using voxel-based morphometry in a sample of 305 patients with heterogeneous patterns of neurodegeneration. Permutation-based analyses were used to determine regions of decreased gray matter volume at a significance level p
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2014.12.031