Comparison of Traditional and Novel Self-Report Measures to an Alcohol Biomarker for Quantifying Alcohol Consumption Among HIV-Infected Adults in Sub-Saharan Africa

Background In Sub‐Saharan Africa (SSA), HIV‐infected patients may underreport alcohol consumption. We compared self‐reports of drinking to phosphatidylethanol (PEth), an alcohol biomarker. In particular, we assessed beverage‐type‐adjusted fractional graduated frequency (FGF) and quantity frequency (...

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Bibliographic Details
Published in:Alcoholism, clinical and experimental research clinical and experimental research, 2015-08, Vol.39 (8), p.1518-1527
Main Authors: Asiimwe, Stephen B., Fatch, Robin, Emenyonu, Nneka I., Muyindike, Winnie R., Kekibiina, Allen, Santos, Glenn-Milo, Greenfield, Thomas K., Hahn, Judith A.
Format: Article
Language:English
Subjects:
Adult
Africa South of the Sahara - epidemiology
Alcohol
Alcohol Drinking - blood
Alcohol Drinking - epidemiology
Biomarkers
Biomarkers - blood
Cohort Studies
Confidence intervals
Cross-Sectional Studies
Female
Fractional Graduated Frequency
Glycerophospholipids - blood
HIV Infections - blood
HIV Infections - diagnosis
HIV Infections - epidemiology
Humans
Lentivirus
Male
Methods
Phosphatidylethanol
Quantity Frequency
Retroviridae
Self Report - standards
Self-Report Measures of Alcohol Consumption
Sub-Saharan Africa
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Summary:Background In Sub‐Saharan Africa (SSA), HIV‐infected patients may underreport alcohol consumption. We compared self‐reports of drinking to phosphatidylethanol (PEth), an alcohol biomarker. In particular, we assessed beverage‐type‐adjusted fractional graduated frequency (FGF) and quantity frequency (QF) measures of grams of alcohol, novel nonvolume measures, and the Alcohol Use Disorders Identification Test‐Consumption (AUDIT‐C). Methods We analyzed cohort entry data from the Biomarker Research of Ethanol Among Those with HIV cohort study (2011 to 2013). Participants were HIV‐infected past‐year drinkers, newly enrolled into care. Self‐report measures included FGF and QF grams of alcohol, the AUDIT‐C, number of drinking days, and novel adaptations of FGF and QF methods to expenditures on alcohol, time spent drinking, and symptoms of intoxication. PEth levels were measured from dried blood spots. We calculated Spearman's rank correlation coefficients of self‐reports with PEth and bias‐corrected bootstrap 95% confidence intervals (CIs) for pairwise differences between coefficients. Results A total of 209 subjects (57% men) were included. Median age was 30; interquartile range (IQR) 25 to 38. FGF grams of alcohol over the past 90 days (median 592, IQR 43 to 2,137) were higher than QF grams (375, IQR 33 to 1,776), p 
ISSN:0145-6008
1530-0277
DOI:10.1111/acer.12781