Complex inhibitory microcircuitry regulates retinal signaling near visual threshold

Neuronal microcircuits, small, localized signaling motifs involving two or more neurons, underlie signal processing and computation in the brain. Compartmentalized signaling within a neuron may enable it to participate in multiple, independent microcircuits. Each A17 amacrine cell in the mammalian r...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of neurophysiology 2015-07, Vol.114 (1), p.341-353
Main Authors:	Grimes, William N, Zhang, Jun, Tian, Hua, Graydon, Cole W, Hoon, Mrinalini, Rieke, Fred, Diamond, Jeffrey S
Format:	Article
Language:	eng
Subjects:	Animals Calcium Channels, L-Type - metabolism Darkness Feedback, Physiological - physiology Immunohistochemistry Immunoprecipitation Large-Conductance Calcium-Activated Potassium Channels - metabolism Mice, Inbred C57BL Neural Inhibition - physiology Patch-Clamp Techniques Photic Stimulation Rats, Sprague-Dawley Receptors, GABA - metabolism Retina - cytology Retina - physiology Sensory Processing Sensory Thresholds - physiology Synapses - physiology Tissue Culture Techniques Vision, Ocular - physiology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Neuronal microcircuits, small, localized signaling motifs involving two or more neurons, underlie signal processing and computation in the brain. Compartmentalized signaling within a neuron may enable it to participate in multiple, independent microcircuits. Each A17 amacrine cell in the mammalian retina contains within its dendrites hundreds of synaptic feedback microcircuits that operate independently to modulate feedforward signaling in the inner retina. Each of these microcircuits comprises a small (
ISSN:	0022-3077 1522-1598