A Tutorial on Target‐Mediated Drug Disposition (TMDD) Models

Target‐mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics. The aim of this Tutorial is to provide an introductory guide to the math...

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Bibliographic Details
Published in:	CPT: pharmacometrics and systems pharmacology 2015-06, Vol.4 (6), p.324-337
Main Authors:	Dua, P, Hawkins, E, van der Graaf, PH
Format:	Article
Language:	eng
Subjects:	Growth factors Immunoglobulins Leukemia Ligands Ordinary differential equations Peptides Proteins Tumor necrosis factor-TNF Tutorial
Online Access:	Get full text
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Summary:	Target‐mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics. The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna code for some models discussed in this Tutorial are provided in the Supplementary Materials.
ISSN:	2163-8306 2163-8306