Diabetic retinopathy in the SEARCH for Diabetes in Youth Cohort: a pilot study

Diabet. Med. 29, 1148–1152 (2012) Aims  The aim of this pilot study was to generate an initial estimate of the prevalence and correlates of diabetic retinopathy in a racially and ethnically diverse sample of youth with Type 1 and Type 2 diabetes mellitus. Methods  A pilot study was conducted among 2...

Full description

Saved in:
Bibliographic Details
Published in:Diabetic medicine 2012-09, Vol.29 (9), p.1148-1152
Main Authors: Mayer-Davis, E. J., Davis, C., Saadine, J., D'Agostino Jr, R. B., Dabelea, D., Dolan, L., Garg, S., Lawrence, J. M., Pihoker, C., Rodriguez, B. L., Klein, B. E., Klein, R.
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Child
childhood diabetes
Cohort Studies
diabetes complications
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - ethnology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - ethnology
Diabetes. Impaired glucose tolerance
Diabetic Retinopathy - epidemiology
Diabetic Retinopathy - ethnology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
epidemiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
European Continental Ancestry Group - ethnology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Humans
Medical sciences
Minority Groups
Pilot Projects
Prevalence
retinopathy
United States - epidemiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabet. Med. 29, 1148–1152 (2012) Aims  The aim of this pilot study was to generate an initial estimate of the prevalence and correlates of diabetic retinopathy in a racially and ethnically diverse sample of youth with Type 1 and Type 2 diabetes mellitus. Methods  A pilot study was conducted among 222 individuals with Type 1 diabetes (79% non‐Hispanic white, 21% other) and 43 with Type 2 diabetes (28% non‐Hispanic white, 72% other), all of > 5 years duration (mean duration 6.8 years) who participated in the SEARCH for Diabetes in Youth study. Diabetic retinopathy was assessed using non‐mydriatic retinal photography of both eyes. Results  The prevalence of diabetic retinopathy was 17% for Type 1 diabetes and 42% for Type 2 diabetes (odds ratio 1.50, 95% CI 0.58–3.88; P = 0.40 adjusted for age, duration, gender, race/ethnicity, parental education and HbA1c. HbA1c was significantly higher among those with any diabetic retinopathy (adjusted mean 79 mmol/mol, 9.4%) vs. no diabetic retinopathy (adjusted mean 70 mmol/mol, 8.6%) (P = 0.015). LDL cholesterol was also significantly higher among those with any diabetic retinopathy (adjusted mean 107.2 mg/dl) compared with those without diabetic retinopathy (adjusted mean 97.9 mg/dl) (P = 0.04). Conclusions  The prevalence of diabetic retinopathy in contemporary young individuals was substantial, particularly among minority youth and those with Type 2 diabetes. Further long‐term study of diabetic retinopathy in youth is needed.
ISSN:0742-3071
1464-5491
1464-5491
DOI:10.1111/j.1464-5491.2012.03591.x