High-Throughput Sequencing Technologies

The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing tech...

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Bibliographic Details
Published in:Molecular cell 2015-05, Vol.58 (4), p.586-597
Main Authors: Reuter, Jason A., Spacek, Damek V., Snyder, Michael P.
Format: Article
Language:English
Subjects:
Genome, Human - genetics
Genomics - methods
High-Throughput Nucleotide Sequencing - methods
Humans
Microbiota - genetics
Neoplasms - genetics
Precision Medicine - methods
Transcriptome - genetics
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Summary:The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years. Here, we discuss commonly used high-throughput sequencing platforms, the growing array of sequencing assays developed around them, as well as the challenges facing current sequencing platforms and their clinical application. Reuter et al. discuss common used high-throughput sequencing platforms, challenges, and applications.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2015.05.004