Nanoparticles for Radiation Therapy Enhancement: the Key Parameters

This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews sho...

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Bibliographic Details
Published in:Theranostics 2015-01, Vol.5 (9), p.1030-1044
Main Authors: Retif, Paul, Pinel, Sophie, Toussaint, Magali, Frochot, Céline, Chouikrat, Rima, Bastogne, Thierry, Barberi-Heyob, Muriel
Format: Article
Language:English
Subjects:
Animals
Cancer
Drug Evaluation, Preclinical
Electromagnetic Radiation
Life Sciences
Nanoparticles - administration & dosage
Radiation-Sensitizing Agents - administration & dosage
Radiotherapy - methods
Review
X-Rays
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Summary:This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.11642