Prevalence of methicillin-resistant Staphylococcus aureus colonization in HIV-infected patients in Barcelona, Spain: a cross-sectional study

Colonization by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been found to be markedly more common in HIV-infected individuals in the USA. Studies evaluating the prevalence MRSA colonization in HIV-infected populations in Europe are scarce. The aim of this study was...

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Bibliographic Details
Published in:BMC infectious diseases 2015-06, Vol.15 (1), p.243-243, Article 243
Main Authors: Imaz, Arkaitz, Camoez, Mariana, Di Yacovo, Silvana, Gasch, Oriol, Dominguez, M Angeles, Vila, Antonia, Maso-Serra, Margarita, Pujol, Miquel, Podzamczer, Daniel
Format: Article
Language:English
Subjects:
Adult
Antibiotics
Antibiòtics
Barcelona (Catalonia : Province)
Barcelona (Catalunya : Província)
Care and treatment
Cities
Cross-Sectional Studies
Drug resistance
Drug resistance in microorganisms
Espanya
Female
Genetic aspects
Health aspects
Highly active antiretroviral therapy
HIV Infections
Humans
Infeccions nosocomials
Infeccions per VIH
Male
Medical records
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Middle Aged
Nosocomial infections
Pharynx - microbiology
Prevalence
Resistència als medicaments
Risk factors
Socioeconomic Factors
Spain
Spain - epidemiology
Staphylococcal Infections - complications
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus infections
Surveys and Questionnaires
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Summary:Colonization by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been found to be markedly more common in HIV-infected individuals in the USA. Studies evaluating the prevalence MRSA colonization in HIV-infected populations in Europe are scarce. The aim of this study was to investigate the prevalence of MRSA colonization in a cohort of HIV-infected patients in Barcelona, Spain. Nasal and pharyngeal S. aureus carriage was assessed in a random sample of 190 patients from an outpatient HIV clinic. Nasal and pharyngeal swab specimens were obtained for staphylococcal culture from 190 and 110 patients respectively. All MRSA isolates were screened for Panton-Valentine leukocidin (PVL) genes by PCR. Molecular characterization of MRSA isolates was performed by multilocus sequence typing. Data related to HIV infection, healthcare exposure, and previously described risk factors for MRSA were collected from medical records and a questionnaire administered to each patient. The patients' characteristics were as follows: male, 83 %; median (IQR) age, 45 (39-49) years; intravenous drug users, 39 %; men who have sex with men, 32 %; heterosexual, 26 %; CD4 count, 528/μL (IQR 351-740); on antiretroviral therapy, 96 %; and undetectable plasma viral load, 80 %. Sixty-five patients (34 %) were colonized by S. aureus. MRSA colonization was found in 1 % and 2 % of nasal and pharyngeal samples respectively. No PVL positive MRSA strains were detected and all the MRSA isolates belonged to typical hospital-acquired clones. Our data suggest that CA-MRSA colonization is not currently a problem in HIV-infected individuals in our area.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-015-0991-z