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Effect of Variation in hemorheology between human and animal blood on the binding efficacy of vascular-targeted carriers
Animal models are extensively used to evaluate the in vivo functionality of novel drug delivery systems (DDS). However, many variations likely exist in vivo between the animals and human physiological environment that significantly alter results obtained with animal models relative to human system....
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| Published in: | Scientific reports 2015-06, Vol.5 (1), p.11631-11631, Article 11631 |
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| creator | Namdee, K. Carrasco-Teja, M. Fish, M. B. Charoenphol, P. Eniola-Adefeso, O. |
| description | Animal models are extensively used to evaluate the
in vivo
functionality of novel drug delivery systems (DDS). However, many variations likely exist
in vivo
between the animals and human physiological environment that significantly alter results obtained with animal models relative to human system. To date, it is not clear if the variation in hemorheology and hemodynamics between common animal and human models affect the functionality of DDS. This study investigates the role of hemorheology of humans and various animal models in dictating the binding efficiency of model vascular-targeted carriers (VTCs) to the wall in physiological blood flows. Specifically, the adhesion of sLe
A
-coated nano- and micro-spheres to inflamed endothelial cells monolayers were conducted
via
a parallel plate flow chamber assay with steady and disturbed red blood cells (RBCs)-in-buffer and whole blood flows of common animal models. Our results suggest that the ratio of carrier size to RBC size dictate particle binding in blood flow. Additionally, the presence of white blood cells affects the trend of particle adhesion depending on the animal species. Overall, this work sheds light on some deviation in VTC vascular wall interaction results obtained with
in vivo
animal experimentation from expected outcome and efficiency
in vivo in
human. |
| doi_str_mv | 10.1038/srep11631 |
| format | article |
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in vivo
functionality of novel drug delivery systems (DDS). However, many variations likely exist
in vivo
between the animals and human physiological environment that significantly alter results obtained with animal models relative to human system. To date, it is not clear if the variation in hemorheology and hemodynamics between common animal and human models affect the functionality of DDS. This study investigates the role of hemorheology of humans and various animal models in dictating the binding efficiency of model vascular-targeted carriers (VTCs) to the wall in physiological blood flows. Specifically, the adhesion of sLe
A
-coated nano- and micro-spheres to inflamed endothelial cells monolayers were conducted
via
a parallel plate flow chamber assay with steady and disturbed red blood cells (RBCs)-in-buffer and whole blood flows of common animal models. Our results suggest that the ratio of carrier size to RBC size dictate particle binding in blood flow. Additionally, the presence of white blood cells affects the trend of particle adhesion depending on the animal species. Overall, this work sheds light on some deviation in VTC vascular wall interaction results obtained with
in vivo
animal experimentation from expected outcome and efficiency
in vivo in
human.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep11631</identifier><identifier>PMID: 26113000</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/31 ; 631/61/54/152 ; 639/166/985 ; 639/925/350/354 ; Adult ; Animal models ; Animals ; Blood flow ; Blood Flow Velocity - physiology ; Cell Adhesion ; Cell Size ; Cells, Cultured ; Drug Carriers - chemistry ; Drug Carriers - metabolism ; Drug delivery ; Drug Delivery Systems - methods ; Endothelial cells ; Erythrocytes ; Erythrocytes - metabolism ; Hemodynamics ; Hemodynamics - physiology ; Hemorheology - physiology ; Human Umbilical Vein Endothelial Cells - metabolism ; Humanities and Social Sciences ; Humans ; Inflammation ; Leukocytes ; Mice ; Microspheres ; Monte Carlo Method ; multidisciplinary ; Nanospheres - chemistry ; Particle Size ; Physiology ; Rabbits ; Science ; Species Specificity ; Swine</subject><ispartof>Scientific reports, 2015-06, Vol.5 (1), p.11631-11631, Article 11631</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Jun 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-6980006da91fd7303d712d68a7947d3a281136405a49dda24d453d2be2480a083</citedby><cites>FETCH-LOGICAL-c504t-6980006da91fd7303d712d68a7947d3a281136405a49dda24d453d2be2480a083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1899485717/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1899485717?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,730,783,787,888,25767,27938,27939,37026,37027,44604,53806,53808,75462</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26113000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Namdee, K.</creatorcontrib><creatorcontrib>Carrasco-Teja, M.</creatorcontrib><creatorcontrib>Fish, M. B.</creatorcontrib><creatorcontrib>Charoenphol, P.</creatorcontrib><creatorcontrib>Eniola-Adefeso, O.</creatorcontrib><title>Effect of Variation in hemorheology between human and animal blood on the binding efficacy of vascular-targeted carriers</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Animal models are extensively used to evaluate the
in vivo
functionality of novel drug delivery systems (DDS). However, many variations likely exist
in vivo
between the animals and human physiological environment that significantly alter results obtained with animal models relative to human system. To date, it is not clear if the variation in hemorheology and hemodynamics between common animal and human models affect the functionality of DDS. This study investigates the role of hemorheology of humans and various animal models in dictating the binding efficiency of model vascular-targeted carriers (VTCs) to the wall in physiological blood flows. Specifically, the adhesion of sLe
A
-coated nano- and micro-spheres to inflamed endothelial cells monolayers were conducted
via
a parallel plate flow chamber assay with steady and disturbed red blood cells (RBCs)-in-buffer and whole blood flows of common animal models. Our results suggest that the ratio of carrier size to RBC size dictate particle binding in blood flow. Additionally, the presence of white blood cells affects the trend of particle adhesion depending on the animal species. Overall, this work sheds light on some deviation in VTC vascular wall interaction results obtained with
in vivo
animal experimentation from expected outcome and efficiency
in vivo in
human.</description><subject>13</subject><subject>13/31</subject><subject>631/61/54/152</subject><subject>639/166/985</subject><subject>639/925/350/354</subject><subject>Adult</subject><subject>Animal models</subject><subject>Animals</subject><subject>Blood flow</subject><subject>Blood Flow Velocity - physiology</subject><subject>Cell Adhesion</subject><subject>Cell Size</subject><subject>Cells, Cultured</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - metabolism</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems - methods</subject><subject>Endothelial cells</subject><subject>Erythrocytes</subject><subject>Erythrocytes - metabolism</subject><subject>Hemodynamics</subject><subject>Hemodynamics - physiology</subject><subject>Hemorheology - physiology</subject><subject>Human Umbilical Vein Endothelial Cells - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukocytes</subject><subject>Mice</subject><subject>Microspheres</subject><subject>Monte Carlo Method</subject><subject>multidisciplinary</subject><subject>Nanospheres - chemistry</subject><subject>Particle Size</subject><subject>Physiology</subject><subject>Rabbits</subject><subject>Science</subject><subject>Species Specificity</subject><subject>Swine</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNplkV9rFDEUxYMottQ--AUk4IsKo_k3M8mLUEqtQsEX9TXcmdyZTZlJ1mSmut_elG2XVQMh4d5fTs7lEPKSs_ecSf0hJ9xy3kj-hJwKpupKSCGeHt1PyHnOt6ysWhjFzXNyIhrOZSmckt9Xw4D9QuNAf0DysPgYqA90g3NMG4xTHHe0w-UXYimuMwQKwZXtZ5hoN8XoaHmxbJB2PjgfRorD4Hvod_ead5D7dYJULZBGXNDRHlLymPIL8myAKeP5w3lGvn-6-nb5ubr5ev3l8uKm6mumlqoxuvhsHBg-uFYy6VouXKOhNap1EoQukzSK1aCMcyCUU7V0okOhNAOm5Rn5uNfdrt2MrsewJJjsNpUB0s5G8PbvTvAbO8Y7q5TmtVBF4M2DQIo_V8yLnX3ucZogYFyz5Y3htdHa8IK-_ge9jWsKZTzLtTFK1y1vC_V2T_Up5pLecDDDmb2P1B4iLeyrY_cH8jHAArzbA7m0wojp6Mv_1P4AMBerMg</recordid><startdate>20150626</startdate><enddate>20150626</enddate><creator>Namdee, K.</creator><creator>Carrasco-Teja, M.</creator><creator>Fish, M. 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B.</au><au>Charoenphol, P.</au><au>Eniola-Adefeso, O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Variation in hemorheology between human and animal blood on the binding efficacy of vascular-targeted carriers</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-06-26</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>11631</spage><epage>11631</epage><pages>11631-11631</pages><artnum>11631</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Current Address: National Nanotechnology Center, National Science and Technology Development Agency, 111 Thailand Science Park,Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani 12120, Thailand.</notes><notes>These authors contributed equally to this work.</notes><abstract>Animal models are extensively used to evaluate the
in vivo
functionality of novel drug delivery systems (DDS). However, many variations likely exist
in vivo
between the animals and human physiological environment that significantly alter results obtained with animal models relative to human system. To date, it is not clear if the variation in hemorheology and hemodynamics between common animal and human models affect the functionality of DDS. This study investigates the role of hemorheology of humans and various animal models in dictating the binding efficiency of model vascular-targeted carriers (VTCs) to the wall in physiological blood flows. Specifically, the adhesion of sLe
A
-coated nano- and micro-spheres to inflamed endothelial cells monolayers were conducted
via
a parallel plate flow chamber assay with steady and disturbed red blood cells (RBCs)-in-buffer and whole blood flows of common animal models. Our results suggest that the ratio of carrier size to RBC size dictate particle binding in blood flow. Additionally, the presence of white blood cells affects the trend of particle adhesion depending on the animal species. Overall, this work sheds light on some deviation in VTC vascular wall interaction results obtained with
in vivo
animal experimentation from expected outcome and efficiency
in vivo in
human.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26113000</pmid><doi>10.1038/srep11631</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4481524 |
| source | Open Access: PubMed Central; Publicly Available Content Database; Full-Text Journals in Chemistry (Open access); Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 13 13/31 631/61/54/152 639/166/985 639/925/350/354 Adult Animal models Animals Blood flow Blood Flow Velocity - physiology Cell Adhesion Cell Size Cells, Cultured Drug Carriers - chemistry Drug Carriers - metabolism Drug delivery Drug Delivery Systems - methods Endothelial cells Erythrocytes Erythrocytes - metabolism Hemodynamics Hemodynamics - physiology Hemorheology - physiology Human Umbilical Vein Endothelial Cells - metabolism Humanities and Social Sciences Humans Inflammation Leukocytes Mice Microspheres Monte Carlo Method multidisciplinary Nanospheres - chemistry Particle Size Physiology Rabbits Science Species Specificity Swine |
| title | Effect of Variation in hemorheology between human and animal blood on the binding efficacy of vascular-targeted carriers |
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