Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development

Neuroblastoma is the one of the most common extracranial childhood malignancies, accounting for ∼15% of tumor-associated deaths in children. It is generally considered that neuroblastoma originates from neural crest cells in the paravertebral sympathetic ganglia and the adrenal medulla. However, the...

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Bibliographic Details
Published in:Oncology letters 2015-06, Vol.9 (6), p.2507-2514
Main Authors: KE, XIAO-XUE, ZHANG, DUNKE, ZHAO, HAILONG, HU, RENJIAN, DONG, ZHEN, YANG, RUI, ZHU, SHUNQIN, XIA, QINGYOU, DING, HAN-FEI, CUI, HONGJUAN
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Biological markers
Cell growth
Coronary vessels
Drug resistance
Genetic aspects
Identification and classification
Morphology
Neuroblastoma
neuroblastoma development
Neurogenesis
Oncology
paired-like homeobox 2b
Pathogenesis
Prognosis
Properties
Rodents
Studies
TH-MYCN mice
Transcription factors
Transgenic animals
Tumors
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Summary:Neuroblastoma is the one of the most common extracranial childhood malignancies, accounting for ∼15% of tumor-associated deaths in children. It is generally considered that neuroblastoma originates from neural crest cells in the paravertebral sympathetic ganglia and the adrenal medulla. However, the mechanism by which neuroblastoma arises during sympathetic neurogenesis and the cellular mechanism that drives neuroblastoma development remains unclear. The present study investigated the cell components during neuroblastoma development in the tyrosine hydroxylase-v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (TH-MYCN) mouse model, a transgenic mouse model of human neuroblastoma. The present study demonstrates that paired-like homeobox 2b (Phox2B)+ neuronal progenitors are the major cellular population in hyperplastic lesions and primary tumors. In addition, Phox2B+ neuronal progenitors in hyperplastic lesions or primary tumors were observed to be in an actively proliferative and undifferentiated state. The current study also demonstrated that high expression levels of Phox2B promotes neuroblastoma cell proliferation and xenograft tumor growth. These findings indicate that the proliferation of undifferentiated Phox2B+ neuronal progenitors is a cellular mechanism that promotes neuroblastoma development and indicates that Phox2B is a critical regulator in neuroblastoma pathogenesis.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.3088