Ductal and Acinar Adenocarcinoma of Prostate: Morphological and Immunohistochemical Characterization

Objectives: We sought to characterize the ductal and acinar subtype of prostate adenocarcinoma using hematoxylin and eosin (H&E) staining and an immunohistochemical antibody cocktail. We also investigated the clinical features, prostate-specific antigen (PSA) levels, and biological aggressivenes...

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Bibliographic Details
Published in:Oman medical journal 2015-05, Vol.30 (3), p.162-166
Main Authors: Syed , Serajuddaula, Baig , Faraz A, Hamid , Amna, Mirza , Talat
Format: Article
Language:English
Subjects:
Acinar Carcinoma
Adenocarcinoma
Cancer
Diagnosis
Ductal Carcinoma
Gleason Score
IMMUNITY
Immunohistochemistry
MALE GENITAL SYSTEM
MEDICAL SCIENCES
NEOPLASMS
Original
PROSTATE
PROSTATITIS
إلتهاب البروستات
الأورام
البروستات
الجهاز التناسلي الذكري
العلوم الطبية
المناعة
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Summary:Objectives: We sought to characterize the ductal and acinar subtype of prostate adenocarcinoma using hematoxylin and eosin (H&E) staining and an immunohistochemical antibody cocktail. We also investigated the clinical features, prostate-specific antigen (PSA) levels, and biological aggressiveness of these tumors. Methods: We utilized tumor bearing prostate biopsies, obtained between 2010 and 2014 from Dow Diagnostic Research and Reference Laboratory, to identify cases of prostatic ductal and acinar adenocarcinoma using routine H&E and immunohistochemical staining. The immunohistochemical antibody cocktail 34βE12/p63/AMACR was used for staining. The association of clinicopathological variables including patient’s age at diagnosis, Gleason score, and PSA levels before surgery was retrospectively analyzed. Results: A total of 10 ductal and 140 non-ductal cases were identified. Ductal cases were predominantly high grade with advanced histopathological features (90%; p=0.030). Marked elevation in PSA level was also reported in most cases. No other significant statistical difference was observed. Conclusions: Pathological and immunohistochemical examination could be used to characterize ductal and acinar adenocarcinoma of the prostate. Ductal adenocarcinoma of the prostate is a rare subtype of prostate carcinoma and is be more likely to present with advanced grade cancer suggesting that timely detection of the disease is vital.
ISSN:1999-768X
2070-5204
DOI:10.5001/omj.2015.36