PDGF-induced proliferation in human arterial and venous smooth muscle cells: Molecular basis for differential effects of PDGF isoforms

Platelet‐derived growth factor (PDGF) has been implicated in the pathogenesis of arterial atherosclerosis and venous neointimal hyperplasia. We examined the effects of PDGF isoforms on smooth muscle cells (SMCs) from arterial and venous origins in order to further understand the differential respons...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2011-01, Vol.112 (1), p.289-298
Main Authors: Li, Li, Blumenthal, Donald K., Terry, Christi M., He, Yuxia, Carlson, Mary L., Cheung, Alfred K.
Format: Article
Language:English
Subjects:
arterial and venous SMC
Arteries - cytology
Arteries - drug effects
Arteries - metabolism
Cell Proliferation
Cyclin-Dependent Kinase Inhibitor p21 - metabolism
Cyclin-Dependent Kinase Inhibitor p27 - metabolism
Flow Cytometry
Humans
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
platelet-derived growth factor (PDGF)
Platelet-Derived Growth Factor - pharmacology
Protein Isoforms - pharmacology
Receptors, Platelet-Derived Growth Factor - metabolism
signaling pathways
Veins - cytology
Veins - drug effects
Veins - metabolism
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Summary:Platelet‐derived growth factor (PDGF) has been implicated in the pathogenesis of arterial atherosclerosis and venous neointimal hyperplasia. We examined the effects of PDGF isoforms on smooth muscle cells (SMCs) from arterial and venous origins in order to further understand the differential responsiveness of these vasculatures to proliferative stimuli. Serum‐starved human arterial and venous SMCs exhibited very different proliferative responses to PDGF isoforms. Whereas, proliferation of arterial SMCs was strongly stimulated by PDGF‐AA, venous SMCs showed no proliferative response to PDGF‐AA, but instead demonstrated a significantly greater proliferative response to PDGF‐BB than arterial SMCs. Part of this difference could be attributed to differences in PDGF receptors expression. There was a 2.5‐fold higher (P 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.22924