Large-scale recent expansion of European patrilineages shown by population resequencing

The proportion of Europeans descending from Neolithic farmers ∼ 10 thousand years ago (KYA) or Palaeolithic hunter-gatherers has been much debated. The male-specific region of the Y chromosome (MSY) has been widely applied to this question, but unbiased estimates of diversity and time depth have bee...

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Bibliographic Details
Published in:	Nature communications 2015-05, Vol.6 (1), p.7152, Article 7152
Main Authors:	Batini, Chiara, Hallast, Pille, Zadik, Daniel, Delser, Pierpaolo Maisano, Benazzo, Andrea, Ghirotto, Silvia, Arroyo-Pardo, Eduardo, Cavalleri, Gianpiero L, de Knijff, Peter, Dupuy, Berit Myhre, Eriksen, Heidi A, King, Turi E, de Munain, Adolfo López, López-Parra, Ana M, Loutradis, Aphrodite, Milasin, Jelena, Novelletto, Andrea, Pamjav, Horolma, Sajantila, Antti, Tolun, Aslıhan, Winney, Bruce, Jobling, Mark A
Format:	Article
Language:	eng
Subjects:	Age composition Bayes Theorem Biological Evolution Chromosomes Computer Simulation Demographics Demography Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Emigration and Immigration Ethnicity - genetics Europe Expansion Genetic Variation Genetics, Population Genomics Geography Haplotypes Historical structures History, Ancient Humans Male Males Middle East Mitochondrial DNA Mutation Nucleotides Phylogeny Population Dynamics Populations Sequence Analysis, DNA Single-nucleotide polymorphism Social conditions Stone Age Whites - genetics Y chromosomes
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Summary:	The proportion of Europeans descending from Neolithic farmers ∼ 10 thousand years ago (KYA) or Palaeolithic hunter-gatherers has been much debated. The male-specific region of the Y chromosome (MSY) has been widely applied to this question, but unbiased estimates of diversity and time depth have been lacking. Here we show that European patrilineages underwent a recent continent-wide expansion. Resequencing of 3.7 Mb of MSY DNA in 334 males, comprising 17 European and Middle Eastern populations, defines a phylogeny containing 5,996 single-nucleotide polymorphisms. Dating indicates that three major lineages (I1, R1a and R1b), accounting for 64% of our sample, have very recent coalescent times, ranging between 3.5 and 7.3 KYA. A continuous swathe of 13/17 populations share similar histories featuring a demographic expansion starting ∼ 2.1-4.2 KYA. Our results are compatible with ancient MSY DNA data, and contrast with data on mitochondrial DNA, indicating a widespread male-specific phenomenon that focuses interest on the social structure of Bronze Age Europe.
ISSN:	2041-1723 2041-1723