Enzyme-activated intracellular drug delivery with tubule clay nanoformulation

Fabrication of stimuli-triggered drug delivery vehicle s is an important milestone in treating cancer. Here we demonstrate the selective anticancer drug delivery into human cells with biocompatible 50-nm diameter halloysite nanotube carriers. Physically-adsorbed dextrin end stoppers secure the inter...

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Bibliographic Details
Published in:Scientific reports 2015-05, Vol.5 (1), p.10560, Article 10560
Main Authors: Dzamukova, Maria R, Naumenko, Ekaterina A, Lvov, Yuri M, Fakhrullin, Rawil F
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Actins - chemistry
Aluminum Silicates - chemistry
Cancer
Carcinoma, Hepatocellular - drug therapy
Cell Line, Tumor
Cell Survival - drug effects
Clay
Dextrin
Dextrins - chemistry
Drug Carriers - pharmacology
Drug delivery
Enzymes
Growth rate
Hepatoma
Humans
Intracellular
Liver Neoplasms - drug therapy
Lung carcinoma
Lung Neoplasms - drug therapy
Microscopy, Atomic Force
Microscopy, Electron, Transmission
Mitochondria - drug effects
Nanotubes
Nanotubes - chemistry
Pharmaceutical Preparations
Quaternary Ammonium Compounds - pharmacology
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Summary:Fabrication of stimuli-triggered drug delivery vehicle s is an important milestone in treating cancer. Here we demonstrate the selective anticancer drug delivery into human cells with biocompatible 50-nm diameter halloysite nanotube carriers. Physically-adsorbed dextrin end stoppers secure the intercellular release of brilliant green. Drug-loaded nanotubes penetrate through the cellular membranes and their uptake efficiency depends on the cells growth rate. Intercellular glycosyl hydrolases-mediated decomposition of the dextrin tube-end stoppers triggers the release of the lumen-loaded brilliant green, which allowed for preferable elimination of human lung carcinoma cells (А549) as compared with hepatoma cells (Hep3b). The enzyme-activated intracellular delivery of brilliant green using dextrin-coated halloysite nanotubes is a promising platform for anticancer treatment.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep10560