Perfluoroalkyl substances and ovarian hormone concentrations in naturally cycling women

Objective To examine associations between environmental exposure to perfluoroalkyl substances (PFASs) and ovarian hormone concentrations in naturally cycling women. Design E2 and P were measured in saliva samples collected daily for a single menstrual cycle and concentrations of PFASs (including per...

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Bibliographic Details
Published in:Fertility and sterility 2015-05, Vol.103 (5), p.1261-1270.e3
Main Authors: Barrett, Emily S., Ph.D, Chen, Chongshu, M.A, Thurston, Sally W., Ph.D, Haug, Line Småstuen, Ph.D, Sabaredzovic, Azemira, M.Sc, Fjeldheim, Frøydis Nyborg, M.D, Frydenberg, Hanne, M.D, Lipson, Susan F., Ph.D, Ellison, Peter T., Ph.D, Thune, Inger, M.D., Ph.D
Format: Article
Language:English
Subjects:
Adult
Alkanesulfonic Acids - blood
Biomarkers - metabolism
endocrine disruptors
Endocrine Disruptors - adverse effects
Endocrine Disruptors - blood
Environmental Exposure
Estradiol - metabolism
Female
Fluorocarbons - adverse effects
Fluorocarbons - blood
Humans
Internal Medicine
Menstrual Cycle - blood
Menstrual Cycle - drug effects
Obstetrics and Gynecology
Ovary - drug effects
Ovary - metabolism
Parity
Perfluoroalkyl substances
PFOS
progesterone
Progesterone - metabolism
Risk Assessment
Saliva - metabolism
Time Factors
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Summary:Objective To examine associations between environmental exposure to perfluoroalkyl substances (PFASs) and ovarian hormone concentrations in naturally cycling women. Design E2 and P were measured in saliva samples collected daily for a single menstrual cycle and concentrations of PFASs (including perfluoroctane sulfonate [PFOS] and perfluoroctanoic acid) were measured in serum samples collected during the same cycle. Setting Not applicable. Patient(s) A total of 178 healthy, naturally cycling women, aged 25–35 years. Intervention(s) None. Main Outcome Measure(s) Mean follicular E2 (cycle days −7 to −1, where 0 is the day of ovulation); mean luteal P (cycle days +2 to 10). Result(s) Among nulliparous, but not parous women, PFOS concentrations were inversely associated with E2 (β = −0.025, 95% CI −0.043, −0.007) and P (β = −0.027, 95% CI −0.048, −0.007). Similar, but weaker results were observed for perfluorooctanesulfonic acid. No associations were observed between other PFASs (including perfluoroctanoic acid) and ovarian steroid concentrations, nor were any associations noted in parous women. Conclusion(s) Our results demonstrate that PFOS and perfluorooctanesulfonic acid may be associated with decreased production of E2 and P in reproductive age women. These results suggest a possible mechanism by which PFASs affect women's health, and underscore the importance of parity in research on PFASs and women's reproductive health.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2015.02.001