Prenatal dietary load of Maillard reaction products combined with postnatal Coca-Cola drinking affects metabolic status of female Wistar rats

To assess the impact of prenatal exposure to Maillard reaction products (MRPs) -rich diet and postnatal Coca-Cola consumption on metabolic status of female rats. Diet rich in MRPs and consumption of saccharose/fructose sweetened soft drinks is presumed to impose increased risk of development of card...

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Bibliographic Details
Published in:Croatian medical journal 2015-04, Vol.56 (2), p.94-103
Main Authors: Gurecká, Radana, Koborová, Ivana, Janšáková, Katarína, Tábi, Tamás, Szökő, Éva, Somoza, Veronika, Šebeková, Katarína, Celec, Peter
Format: Article
Language:English
Subjects:
Advanced glycation end products
Animals
Blood Glucose - metabolism
Body Weight - drug effects
Carbonated Beverages
Diet
Female
Glucose Tolerance Test
Health aspects
Lipid Metabolism
Maillard Reaction
Metabolic Diseases - blood
Metabolic Diseases - etiology
Metabolism
Mother and child
Oxidative Stress
Pregnancy
Prenatal Exposure Delayed Effects - etiology
Prenatal Nutritional Physiological Phenomena
Rats
Rats, Wistar
RECOOP for Common Mechanisms of Diseases
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:To assess the impact of prenatal exposure to Maillard reaction products (MRPs) -rich diet and postnatal Coca-Cola consumption on metabolic status of female rats. Diet rich in MRPs and consumption of saccharose/fructose sweetened soft drinks is presumed to impose increased risk of development of cardiometabolic afflictions, such as obesity or insulin resistance. At the first day of pregnancy, 9 female Wistar rats were randomized into two groups, pair-fed either with standard rat chow (MRP-) or MRPs-rich diet (MRP+). Offspring from each group of mothers was divided into two groups and given either water (Cola-) or Coca-Cola (Cola+) for drinking ad libitum for 18 days. Oral glucose tolerance test was performed, and circulating markers of inflammation, oxidative stress, glucose and lipid metabolism were assessed. MRP+ groups had higher weight gain, significantly so in the MRP+/Cola- vs MRP-/Cola-. Both prenatal and postnatal intervention increased carboxymethyllysine levels and semicarbazide-sensitive amine oxidase activity, both significantly higher in MRP+/Cola + than in MRP-/Cola-. Total antioxidant capacity was lower in MRP+ groups, with significant decrease in MRP+/Cola + vs MRP-/Cola+. Rats drinking Coca-Cola had higher insulin, homeostatic model assessment of insulin resistance, heart rate, advanced oxidation of protein products, triacylglycerols, and oxidative stress markers measured as thiobarbituric acid reactive substances compared to rats drinking water, with no visible effect of MRPs-rich diet. Metabolic status of rats was affected both by prenatal and postnatal dietary intervention. Our results suggest that combined effect of prenatal MRPs load and postnatal Coca-Cola drinking may play a role in development of metabolic disorders in later life.
ISSN:0353-9504
1332-8166
DOI:10.3325/cmj.2015.56.94