Cellular factors modulating the mechanism of tau protein aggregation

Pathological accumulation of the microtubule-associated protein tau, in the form of neurofibrillary tangles, is a major hallmark of Alzheimer’s disease, the most prevalent neurodegenerative condition worldwide. In addition to Alzheimer’s disease, a number of neurodegenerative diseases, called tauopa...

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Bibliographic Details
Published in:Cellular and Molecular Life Sciences 2015-05, Vol.72 (10), p.1863-1879
Main Authors: Fontaine, Sarah N, Sabbagh, Jonathan J, Baker, Jeremy, Martinez-Licha, Carlos R, Darling, April, Dickey, Chad A
Format: Article
Language:English
Subjects:
Acetylation
Alzheimer disease
Alzheimer Disease - physiopathology
Alzheimer's disease
Biochemistry
Biomedical and Life Sciences
Biomedicine
brain
Cell Biology
dissociation
Glycosylation
Heat-Shock Proteins - metabolism
Humans
Life Sciences
microtubules
Microtubules - metabolism
molecular chaperones
Molecular Chaperones - metabolism
Neurodegeneration
neurodegenerative diseases
Pathology
Phosphorylation
post-translational modification
Protein Aggregation, Pathological - metabolism
Proteins
Proteolysis
Review
tau Proteins - genetics
tau Proteins - metabolism
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Summary:Pathological accumulation of the microtubule-associated protein tau, in the form of neurofibrillary tangles, is a major hallmark of Alzheimer’s disease, the most prevalent neurodegenerative condition worldwide. In addition to Alzheimer’s disease, a number of neurodegenerative diseases, called tauopathies, are characterized by the accumulation of aggregated tau in a variety of brain regions. While tau normally plays an important role in stabilizing the microtubule network of the cytoskeleton, its dissociation from microtubules and eventual aggregation into pathological deposits is an area of intense focus for therapeutic development. Here we discuss the known cellular factors that affect tau aggregation, from post-translational modifications to molecular chaperones.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-015-1839-9