Sleep loss activates cellular inflammation and signal transducer and activator of transcription (STAT) family proteins in humans

Highlights • Sleep loss activates spontaneous cellular innate immunity. • Sleep loss activates spontaneous monocytic production of inflammatory cytokines. • Sleep loss activates signal transducer and activator of transcription family proteins. • Sleep loss promotes an inflammatory microenvironment t...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-07, Vol.47, p.86-92
Main Authors: Irwin, Michael R, Witarama, Tuff, Caudill, Marissa, Olmstead, Richard, Breen, Elizabeth Crabb
Format: Article
Language:English
Subjects:
Adult
Aged
Allergy and Immunology
Female
Flow cytometry
Humans
Immunology
Inflammation
Inflammation - immunology
Inflammation - metabolism
Interleukin-6
Interleukin-6 - metabolism
Leukocytes, Mononuclear - metabolism
Male
Middle Aged
Monocytes
Monocytes - metabolism
Psychiatry
Signal transducer and activator of transcription
Sleep
Sleep deprivation
Sleep Deprivation - immunology
Sleep Deprivation - metabolism
STAT1 Transcription Factor - metabolism
STAT3 Transcription Factor - metabolism
STAT5 Transcription Factor - metabolism
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-α
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Description
Summary:Highlights • Sleep loss activates spontaneous cellular innate immunity. • Sleep loss activates spontaneous monocytic production of inflammatory cytokines. • Sleep loss activates signal transducer and activator of transcription family proteins. • Sleep loss promotes an inflammatory microenvironment that increases risk for disease.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2014.09.017