Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain

Highlights • RSD increased adhesion molecule and chemokine expression in the brain in an exposure-dependent manner. • Increased protein expression of adhesion molecules VCAM-1 and ICAM-1 was observed on brain vasculature after RSD. • RSD-induced VCAM-1 and ICAM-1 protein expression were localized in...

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Bibliographic Details
Published in:Neuroscience 2015-08, Vol.302, p.151-164
Main Authors: Sawicki, C.M, McKim, D.B, Wohleb, E.S, Jarrett, B.L, Reader, B.F, Norden, D.M, Godbout, J.P, Sheridan, J.F
Format: Article
Language:English
Subjects:
adhesion molecules
Analysis of Variance
Animals
Astrocytes - metabolism
Brain - metabolism
Brain - pathology
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - metabolism
chemokines
Chemokines - genetics
Chemokines - metabolism
Disease Models, Animal
Endothelium - metabolism
Gene Expression Regulation - physiology
Male
Mice
Microglia - metabolism
myeloid cell trafficking
Myeloid Cells - metabolism
Neurology
neurovascular unit
reactive endothelium
RNA, Messenger - metabolism
Selectins - genetics
Selectins - metabolism
social defeat
Stress, Psychological - pathology
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Summary:Highlights • RSD increased adhesion molecule and chemokine expression in the brain in an exposure-dependent manner. • Increased protein expression of adhesion molecules VCAM-1 and ICAM-1 was observed on brain vasculature after RSD. • RSD-induced VCAM-1 and ICAM-1 protein expression were localized in brain regions implicated in fear and anxiety responses. • IL-1β, CXCL2, and CCL2 expression were increased after RSD in enriched microglia/macrophages, but not in astrocytes. • Increased adhesion molecule and chemokine expression facilitated myeloid cell recruitment to the brain with stress.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.10.004