Tailored radiotherapeutic strategies for disseminated uterine cervical cancer patients

To investigate the role of radiotherapy (RT) in and to suggest radiotherapeutic strategies for patients presenting with disseminated cervical cancer. We retrospectively analyzed 50 patients diagnosed as the disseminated cervical cancer with distant lymph nodal or visceral organ metastasis between Se...

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Bibliographic Details
Published in:Radiation oncology (London, England) England), 2015-04, Vol.10 (1), p.77-77, Article 77
Main Authors: Im, Jung Ho, Yoon, Hong In, Kim, Sunghoon, Nam, Eun Ji, Kim, Sang Wun, Yim, Ga Won, Keum, Ki Chang, Kim, Young Tae, Kim, Gwi Eon, Kim, Yong Bae
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - radiotherapy
Adenocarcinoma - secondary
Adult
Aged
Brachytherapy
Cancer
Cancer patients
Carcinoma, Small Cell - mortality
Carcinoma, Small Cell - radiotherapy
Carcinoma, Small Cell - secondary
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - radiotherapy
Carcinoma, Squamous Cell - secondary
Care and treatment
Cervical cancer
Chemotherapy
Development and progression
Diagnosis
Female
Follow-Up Studies
Health aspects
Humans
Lymphatic Metastasis
Metastasis
Middle Aged
Neoplasm Staging
Patient outcomes
Prognosis
Radiotherapy
Radiotherapy Dosage
Retrospective Studies
Survival Rate
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - radiotherapy
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Summary:To investigate the role of radiotherapy (RT) in and to suggest radiotherapeutic strategies for patients presenting with disseminated cervical cancer. We retrospectively analyzed 50 patients diagnosed as the disseminated cervical cancer with distant lymph nodal or visceral organ metastasis between September 1980 and August 2012. Patients were divided into two subgroups according to visceral organ metastasis: 35 patients diagnosed with distant lymph node metastasis only (group A) and 15 patients with visceral organ metastasis (group B). All patients received external beam RT to the pelvis (median dose 45 Gy) and high-dose rate intracavitary RT (median dose 30 Gy). Thirty-nine patients (78%) received chemotherapy. Median follow-up time was 74 months. The 5-year pelvic control rate (PCR) was 85.8%, and the progression-free survival (PFS), and overall survival (OS) rates were 28.7%, and 36.2%, respectively. The major treatment failure was systemic progression (32 patients, 64%). The 5-year PCRs in groups A and B were 87.4% and 74.7%, respectively (p > 0.05). Meanwhile, PFS and OS rates for group A were significantly better than those for group B (35.3% vs. 13.3%, p = 0.010; and 46.3% vs. 13.3%, p = 0.009, respectively). Our data revealed considerable prognostic heterogeneity in disseminated cervical cancer. Even though a high PCR was achieved in patients treated with definitive RT, survival outcomes were dependent on progression of visceral organ metastasis. Therefore, personalized RT and chemotherapy treatment strategies according to the presence of visceral organ metastasis in disseminated cervical cancer patients may help improve clinical outcomes.
ISSN:1748-717X
1748-717X
DOI:10.1186/s13014-015-0373-0