The role of myofibroblasts in wound healing, contraction and its clinical implications in cleft palate repair

Myofibroblasts after its discovery in 1971 as the principal cell for wound healing has come a long way as far as research is concerned. The primary focus of research has been regarding preventing certain unwanted effects of this cell such as wound contraction and scarring. As far as the oral and max...

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Bibliographic Details
Published in:Journal of international oral health 2015-03, Vol.7 (3), p.75-80
Main Authors: Chitturi, Ravi Teja, Balasubramaniam, A Murali, Parameswar, R Arjun, Kesavan, G, Haris, K T Muhamed, Mohideen, Khadijah
Format: Article
Language:English
Subjects:
Apoptosis
Cell adhesion & migration
Extracellular matrix
Proteins
Review
Smooth muscle
Wound healing
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Summary:Myofibroblasts after its discovery in 1971 as the principal cell for wound healing has come a long way as far as research is concerned. The primary focus of research has been regarding preventing certain unwanted effects of this cell such as wound contraction and scarring. As far as the oral and maxillofacial region is concerned, the primary concern of this untoward effect is during repair of cleft palate surgically which results impaired development of palate and the dentoalveolar structures. This review focuses on the basic aspects of myofibroblasts such as its origin, formation, function in wound healing, role in wound contraction and ways by which its unwanted effects can be overcome to improve the quality of the post surgical complications of cleft palate surgery.
ISSN:0976-7428
0976-1799