The complex portal--an encyclopaedia of macromolecular complexes

The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/complex), through which protein complexes from major model organisms are being collated and made available for search, viewing and download. It has been...

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Bibliographic Details
Published in:Nucleic acids research 2015-01, Vol.43 (Database issue), p.D479-D484
Main Authors: Meldal, Birgit H M, Forner-Martinez, Oscar, Costanzo, Maria C, Dana, Jose, Demeter, Janos, Dumousseau, Marine, Dwight, Selina S, Gaulton, Anna, Licata, Luana, Melidoni, Anna N, Ricard-Blum, Sylvie, Roechert, Bernd, Skyzypek, Marek S, Tiwari, Manu, Velankar, Sameer, Wong, Edith D, Hermjakob, Henning, Orchard, Sandra
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Database Issue
Databases, Protein
Humans
Internet
Macromolecular Substances - chemistry
Mice
Protein Binding
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
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Summary:The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/complex), through which protein complexes from major model organisms are being collated and made available for search, viewing and download. It has been built in close collaboration with other bioinformatics services and populated with data from ChEMBL, MatrixDB, PDBe, Reactome and UniProtKB. Each entry contains information about the participating molecules (including small molecules and nucleic acids), their stoichiometry, topology and structural assembly. Complexes are annotated with details about their function, properties and complex-specific Gene Ontology (GO) terms. Consistent nomenclature is used throughout the resource with systematic names, recommended names and a list of synonyms all provided. The use of the Evidence Code Ontology allows us to indicate for which entries direct experimental evidence is available or if the complex has been inferred based on homology or orthology. The data are searchable using standard identifiers, such as UniProt, ChEBI and GO IDs, protein, gene and complex names or synonyms. This reference resource will be maintained and grow to encompass an increasing number of organisms. Input from groups and individuals with specific areas of expertise is welcome.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gku975