TRPV4 Channel Cooperativity in the Resistance Vasculature

The cardiovascular system is composed of a muscular pump and a distribution network of arteries, veins, and capillaries. Within this integrated system, it is the responsibility of resistance arteries to regulate tissue perfusion. To effectively control the magnitude and distribution of organ blood f...

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Bibliographic Details
Published in:Biophysical journal 2015-03, Vol.108 (6), p.1312-1313
Main Author: Welsh, Donald G.
Format: Article
Language:English
Subjects:
Calcium
Cardiovascular system
Models, Molecular
New and Notable
Tissues
TRPV Cation Channels - metabolism
Veins & arteries
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Summary:The cardiovascular system is composed of a muscular pump and a distribution network of arteries, veins, and capillaries. Within this integrated system, it is the responsibility of resistance arteries to regulate tissue perfusion. To effectively control the magnitude and distribution of organ blood flow, resistance arteries respond to a range of mechanical, neural, and metabolic stimuli. These stimuli alter arterial tone through cell-specific receptors whose signaling is intimately tied to the mobilization of Ca... (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0006-3495
1542-0086
DOI:10.1016/j.bpj.2015.01.035