Long‐term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers

The circadian clock in peripheral tissues can be entrained by restricted feeding (RF), a regimen that restricts the duration of food availability with no calorie restriction (CR). However, it is not known whether RF can delay the occurrence of age‐associated changes similar to CR. We measured circad...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2011-12, Vol.15 (12), p.2745-2759
Main Authors: Sherman, Hadas, Frumin, Idan, Gutman, Roee, Chapnik, Nava, Lorentz, Axel, Meylan, Jenny, le Coutre, Johannes, Froy, Oren
Format: Article
Language:English
Subjects:
Adipose tissue
Animals
Arginase
Biomarkers - metabolism
Blotting, Western
Body Weight
Caloric Restriction
circadian
Circadian rhythm
Circadian Rhythm - physiology
Circadian rhythms
Cytokines - genetics
Cytokines - metabolism
Dietary restrictions
disease
Experiments
Fluorides
Food
Food availability
Gene expression
Glycerol
Heart - physiology
Humidity
IL-1β
inflammation
Inflammation - genetics
Inflammation - metabolism
Interleukin 6
Interleukin-10 - genetics
Interleukin-10 - metabolism
Interleukin-1alpha - genetics
Interleukin-1alpha - metabolism
Interleukin-1beta - genetics
Interleukin-1beta - metabolism
Interleukin-6 - genetics
Interleukin-6 - metabolism
Jejunum
Kinases
Life expectancy
Liver
Liver diseases
Male
metabolism
Mice
Mice, Inbred C57BL
Monoclonal antibodies
Motor Activity
mRNA
Neoplasms - metabolism
NF-kappa B - genetics
NF-kappa B - metabolism
NF-κB protein
Nutrient deficiency
Original
Physiology
Polyclonal antibodies
Proteins
Real-Time Polymerase Chain Reaction
restricted feeding
RNA, Messenger - genetics
Small intestine
Software
Thrombosis - metabolism
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:The circadian clock in peripheral tissues can be entrained by restricted feeding (RF), a regimen that restricts the duration of food availability with no calorie restriction (CR). However, it is not known whether RF can delay the occurrence of age‐associated changes similar to CR. We measured circadian expression of clock genes, disease marker genes, metabolic factors and inflammatory and allergy markers in mouse serum, liver, jejunum and white adipose tissue (WAT) after long‐term RF of 4 months. We found that circadian rhythmicity is more robust and is phase advanced in most of the genes and proteins tested under RF. In addition, average daily levels of some disease and inflammatory markers were reduced under RF, including liver Il‐6 mRNA, tumour necrosis factor (TNF)‐α and nuclear factor κB (NF‐κB) protein; jejunum Arginase, Afp, Gadd45β, Il‐1α and Il‐1β mRNA, and interleukin (IL)‐6 and TNF‐α protein and WAT Il‐6, Il‐1β, Tnfα and Nfκb mRNA. In contrast, the anti‐inflammatory cytokine Il‐10 mRNA increased in the liver and jejunum. Our results suggest that RF may share some benefits with those of CR. As RF is a less harsh regimen to follow than CR, the data suggest it could be proposed for individuals seeking to improve their health.
ISSN:1582-1838
1582-4934
DOI:10.1111/j.1582-4934.2010.01160.x