Monocyte and Lymphocyte Activation in Bipolar Disorder: A New Piece in the Puzzle of Immune Dysfunction in Mood Disorders

Background: This study tested the hypothesis that the low-grade inflammation presented in patients with bipolar disorder (BD) is associated with expansion of activated T cells, and this activated state may be due to a lack of peripheral regulatory cells. Methods: Specifically, we investigated the di...

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Published in:The international journal of neuropsychopharmacology 2015-01, Vol.18 (1), p.pyu021-pyu021
Main Authors: Barbosa, Izabela Guimarães, Rocha, Natália Pessoa, Assis, Frankcinéia, Vieira, Érica Leandro Marciano, Soares, Jair C, Bauer, Moises Evandro, Teixeira, Antônio Lúcio
Format: Article
Language:English
Subjects:
Bipolar Disorder - blood
Bipolar Disorder - immunology
Blood Chemical Analysis
Cytokines - blood
Female
Flow Cytometry
Humans
Interleukin-10 - metabolism
Logistic Models
Lymphocyte Activation - immunology
Male
Middle Aged
Monocytes - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:Background: This study tested the hypothesis that the low-grade inflammation presented in patients with bipolar disorder (BD) is associated with expansion of activated T cells, and this activated state may be due to a lack of peripheral regulatory cells. Methods: Specifically, we investigated the distribution of monocytes and lymphocyte subsets, and investigated Th1/Th2/Th17 cytokines in plasma by flow cytometry. Twenty-one BD type I patients and 21 age- and sex-matched controls were recruited for this study. Results: BD patients had increased proportions of monocytes (CD14+). Regarding lymphocyte populations, BD patients presented reduced proportions of T cells (CD3+) and cytotoxic T cells (CD3+CD8+). BD patients also exhibited a higher percentage of activated T CD4+CD25+ cells, and a lower percentage of IL-10 expressing Treg cells. Conclusions: Our data shed some light into the underlying mechanisms involved with the chronic low-grade inflammatory profile described in BD patients.
ISSN:1461-1457
1469-5111
DOI:10.1093/ijnp/pyu021