Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation

The purpose of this study was to investigate the impact of metabolic syndrome (MS) on outcome of catheter ablation (CA) for treatment of frequent premature ventricular contraction beats (PVCs) originating from right ventricular outflow tract (RVOT), left ventricular outflow tract (LVOT) or coronary...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2014-12, Vol.14 (1), p.176-176, Article 176
Main Authors: Sardu, Celestino, Carreras, Giovanni, Katsanos, Spyridon, Kamperidis, Vasileios, Pace, Maria Caterina, Passavanti, Maria Beatrice, Fava, Ilaria, Paolisso, Pasquale, Pieretti, Gorizio, Nicoletti, Giovanni Francesco, Santulli, Gaetano, Paolisso, Giuseppe, Marfella, Raffaele
Format: Article
Language:English
Subjects:
Arrhythmia
Cardiology
Care and treatment
Catheter Ablation
Cholesterol
Electrocardiography
Health aspects
Heart attacks
Humans
Medical equipment and supplies industry
Medical research
Medical test kit industry
Medicine, Experimental
Metabolic syndrome
Metabolic Syndrome - complications
Patient outcomes
Pharmaceutical industry
Prospective Studies
Recurrence
Treatment Outcome
Type 2 diabetes
Ventricular Premature Complexes - complications
Ventricular Premature Complexes - surgery
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Summary:The purpose of this study was to investigate the impact of metabolic syndrome (MS) on outcome of catheter ablation (CA) for treatment of frequent premature ventricular contraction beats (PVCs) originating from right ventricular outflow tract (RVOT), left ventricular outflow tract (LVOT) or coronary cusps (CUSPs), in patients with normal ventricular systolic function and absence of cardiac structural disease. In this multicentre prospective study we evaluated 90 patients with frequent PVCs originating from RVOT (n = 68), LVOT (n = 19) or CUSPs (n = 3), treated with CA. According to baseline diagnosis they were divided in patients with MS (n = 24) or without MS (n = 66). The study endpoint was a composite of recurrence of acute or delayed outflow tract ventricular arrhythmia: acute spontaneous or inducible outflow tract ventricular arrhythmia recurrence or recurrence of outflow tract PVCs in holter monitoring at follow up. Patients with MS compared to patients without MS showed a higher acute post-procedural recurrence of outflow tract PVCs (n = 8, 66.6%, vs. n = 6, 9.0%, p = 0.005). At a mean follow up of 35 (17-43) months survival free of recurrence of outflow tract PVCs was lower in patients with baseline MS compared to patients without MS diagnosis (log-rank test, p 
ISSN:1471-2261
1471-2261
DOI:10.1186/1471-2261-14-176